One‐Pot Synthesis of 3‐Aryl‐5‐amino‐1,2,4‐thiadiazoles from Imidates and Thioureas by I2‐Mediated Oxidative Construction of the N–S Bond,European Journal of Organic Chemistry

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One‐Pot Synthesis of 3‐Aryl‐5‐amino‐1,2,4‐thiadiazoles from Imidates and Thioureas by I2‐Mediated Oxidative Construction of the N–S Bond
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-09 , DOI: 10.1002/ejoc.201800670
Ling Chai ₁ , Zhenzhen Lai ₁ , Qiangqiang Xia ₁ , Jiangpei Yuan ₁ , Qilong Bian ₁ , Mingjian Yu ₁ , Wenkai Zhang ₁ , Yuanqing Xu ₁ , Hao Xu _{1,

2}

Affiliation

A simple and practical method for the one‐pot synthesis of 3‐aryl‐5‐amino‐1,2,4‐thiadiazoles from imidates and thioureas has been developed. The protocol proceeds through sequential base‐mediated nucleophilic addition‐elimination reactions and an I₂‐mediated oxidative coupling for the N–S bond formation.