Tough and Self‐Recoverable Thin Hydrogel Membranes for Biological Applications,Advanced Functional Materials

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Tough and Self‐Recoverable Thin Hydrogel Membranes for Biological Applications
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-06-03 , DOI: 10.1002/adfm.201801489
Ya Nan Ye ₁ , Martin Frauenlob ₁ , Lei Wang _{2,

3} , Masumi Tsuda _{2,

3} , Tao Lin Sun _{3,

4} , Kunpeng Cui ₄ , Riku Takahashi ₁ , Hui Jie Zhang ₁ , Tasuku Nakajima _{3,

4} , Takayuki Nonoyama _{3,

4} , Takayuki Kurokawa _{3,

4} , Shinya Tanaka _{2,

3} , Jian Ping Gong _{3,

4}

Affiliation

Tough and self‐recoverable hydrogel membranes with micrometer‐scale thickness are promising for biomedical applications, which, however, rarely be realized due to the intrinsic brittleness of hydrogels. In this work, for the first time, by combing noncovalent DN strategy and spin‐coating method, we successfully fabricated thin (thickness: 5–100 µm), yet tough (work of extension at fracture: 10⁵–10⁷ J m⁻³) and 100% self‐recoverable hydrogel membranes with high water content (62–97 wt%) in large size (≈100 cm²). Amphiphilic triblock copolymers, which form physical gels by self‐assembly, were used for the first network. Linear polymers that physically associate with the hydrophilic midblocks of the first network, were chosen for the second network. The inter‐network associations serve as reversible sacrificial bonds that impart toughness and self‐recovery properties on the hydrogel membranes. The excellent mechanical properties of these obtained tough and thin gel membranes are comparable, or even superior to many biological membranes. The in vitro and in vivo tests show that these hydrogel membranes are biocompatible, and postoperative nonadhesive to neighboring organs. The excellent mechanical and biocompatible properties make these thin hydrogel membranes potentially suitable for use as biological or postoperative antiadhesive membranes.

中文翻译：

适用于生物应用的坚韧且可自我恢复的薄水凝胶膜

具有微米级厚度的坚韧且可自我恢复的水凝胶膜在生物医学应用中很有希望，但是由于水凝胶的固有脆性，这种膜很少见。在这项工作中，在第一次，通过梳理非共价DN策略和旋涂的方法，我们成功地制造薄（厚度：5-100微米），但韧（扩展的工作在骨折：10 ⁵ -10 ⁷缩略词^{- 3}）和大尺寸（≈100cm ²）具有高水含量（62–97 wt％）的100％自恢复水凝胶膜）。两性三嵌段共聚物通过自组装形成物理凝胶，被用于第一个网络。选择与第一网络的亲水性中嵌段物理缔合的线性聚合物作为第二网络。网络间的关联是可逆的牺牲键，可赋予水凝胶膜以韧性和自我恢复的特性。这些获得的坚硬而薄的凝胶膜的优异机械性能是可比的，甚至优于许多生物膜。体外和体内试验表明，这些水凝胶膜具有生物相容性，并且术后对周围器官不粘附。优异的机械和生物相容性使这些薄的水凝胶膜潜在地适合用作生物或术后抗粘膜。

更新日期：2018-06-03

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