Preclinical Antiviral Testing for Dengue Virus Infection in Mouse Models and Its Association with Clinical Studies,ACS Infectious Diseases

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Preclinical Antiviral Testing for Dengue Virus Infection in Mouse Models and Its Association with Clinical Studies
ACS Infectious Diseases ( IF 4.0 ) Pub Date : 2018-05-14 00:00:00 , DOI: 10.1021/acsinfecdis.8b00054
Satoru Watanabe ₁ , Jenny Guek-Hong Low _{1,

2} , Subhash G. Vasudevan ₁

Affiliation

At present, there is no licensed antiviral drug against dengue virus (DENV) infection. Mouse models of DENV infection have been widely used for preclinical evaluation of antivirals. However, only in a few instances so far have the data obtained from preclinical mouse model testing been associated with data from clinical studies in humans. In this Review, we focus on the antiviral drugs targeting viral replication that have been tested in animals/humans and discuss how preclinical drug evaluation in suitable mouse/animal models may be more fruitfully used to inform early phase clinical testing.

中文翻译：

小鼠模型中登革病毒感染的临床前抗病毒检测及其与临床研究的关系

目前，没有获得许可的抗登革热病毒（DENV）感染的抗病毒药。DENV感染的小鼠模型已被广泛用于抗病毒药物的临床前评估。但是，到目前为止，仅在少数情况下，从临床前小鼠模型测试获得的数据与人类临床研究的数据相关联。在本综述中，我们重点关注已在动物/人类中测试过的针对病毒复制的抗病毒药物，并讨论如何在合适的小鼠/动物模型中进行临床前药物评估，以更有效地用于早期临床试验。

更新日期：2018-05-14

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