Organic Solvent and Surfactant Free Fluorescent Organic Nanoparticles by Laser Ablation of Aggregation‐Induced Enhanced Emission Dyes,Advanced Optical Materials

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Organic Solvent and Surfactant Free Fluorescent Organic Nanoparticles by Laser Ablation of Aggregation‐Induced Enhanced Emission Dyes
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2018-05-29 , DOI: 10.1002/adom.201800164
Chang-Keun Lim ₁ , Anton A. Popov ₂ , Gleb Tselikov ₂ , Jeongyun Heo ₃ , Artem Pliss ₁ , Sehoon Kim ₃ , Andrei V. Kabashin _{2,

4} , Paras N. Prasad _{1,

4}

Affiliation

Less toxic and highly fluorescent nanoparticles are in high demand to image biological events and early‐stage disease. A strategy to fabricate highly fluorescent organic nanoparticles by laser ablation of aggregation‐induced enhanced emission (AIE) luminophores, which are free of any organic solvent and surfactant, is presented. As these dyes provide no concentration quenching, the increased number of photoluminescent molecules in a nanoparticle produces bright fluorescence even with their small size (<2 nm), making them highly suitable for intracellular uptake and imaging for a variety of biomedical applications. The design and synthesis of a new AIE luminophore, DCEtDCS, are reported and its photoluminescent quantum yield enhancement up to 58% in the aggregated state is demonstrated. Extremely stable nanoparticles of this luminophore with a narrow size distribution, by laser ablation in water are reported and its superior optical properties that are comparable to quantum dots are verified. The highly negative surface charge of these nanoparticles impedes cellular uptake, but when the surface is coated with chitosan, a cationic polymer, intracellular uptake in microglia is achieved. The strategy provides a novel tool to produce in water, ultrasmall and surfactant‐free highly fluorescent organic nanoparticles suitable for biomedical applications.

中文翻译：

激光烧蚀聚集诱导的增强发射染料的有机溶剂和无表面活性剂的荧光有机纳米粒子

对生物事件和早期疾病成像的低毒性和高荧光纳米颗粒的需求量很大。提出了一种通过激光烧蚀聚集诱导的增强发射（AIE）发光体（不含任何有机溶剂和表面活性剂）来制造高荧光有机纳米粒子的策略。由于这些染料没有提供浓度猝灭，因此纳米颗粒中数量增加的光致发光分子即使具有很小的尺寸（<2 nm）也可以产生明亮的荧光，这使其非常适合细胞内摄取和各种生物医学应用的成像。报道了一种新型AIE发光体DCEtDCS的设计与合成，并证明了其在聚集态下的光致发光量子产率提高了58％。据报道，通过在水中进行激光烧蚀，具有狭窄尺寸分布的这种发光体的极其稳定的纳米粒子，并证实了其与量子点相当的优异光学性质。这些纳米颗粒的高度负表面电荷会阻止细胞摄取，但是当表面用壳聚糖（一种阳离子聚合物）包被时，可以实现小胶质细胞内的摄取。该策略提供了一种新颖的工具，可以在水中生产适用于生物医学应用的超小且不含表面活性剂的高荧光有机纳米颗粒。阳离子聚合物，实现了小胶质细胞的摄取。该策略提供了一种新颖的工具，可以在水中生产适用于生物医学应用的超小且不含表面活性剂的高荧光有机纳米颗粒。阳离子聚合物，实现了小胶质细胞的摄取。该策略提供了一种新颖的工具，可以在水中生产适用于生物医学应用的超小且不含表面活性剂的高荧光有机纳米颗粒。

更新日期：2018-05-29

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