Synthesis ( IF 2.2 ) Pub Date : 2018-05-30 , DOI: 10.1055/s-0037-1609731 Renato Dalpozzo 1 , Raffaella Mancuso 1
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Abstract
Oxindoles represent an important class of bioactive compounds and synthetic derivatives found in many natural products. Most of these compounds are chiral molecules and the challenge of their asymmetric synthesis has fascinated many research groups. In particular, the creation of chiral centers out of the oxindole ring by vinylogous addition to 3-alkylidene-substituted oxindoles (3-alkylidene-1,3-dihydro-2H-indol-2-ones) has emerged in recent years. This review aims to give an overview of this topic.
1 Introduction
2 Aldol and Mannich Reactions
3 Addition to Unsaturated Carbonyl Compounds
4 Addition to Nitroalkenes
5 Miscellaneous
6 Conclusion
Oxindoles represent an important class of bioactive compounds and synthetic derivatives found in many natural products. Most of these compounds are chiral molecules and the challenge of their asymmetric synthesis has fascinated many research groups. In particular, the creation of chiral centers out of the oxindole ring by vinylogous addition to 3-alkylidene-substituted oxindoles (3-alkylidene-1,3-dihydro-2H-indol-2-ones) has emerged in recent years. This review aims to give an overview of this topic.
1 Introduction
2 Aldol and Mannich Reactions
3 Addition to Unsaturated Carbonyl Compounds
4 Addition to Nitroalkenes
5 Miscellaneous
6 Conclusion
中文翻译：
3-亚烷基氧吲哚的对映选择性乙烯基反应
摘要
吲哚代表许多天然产物中发现的一类重要的生物活性化合物和合成衍生物。这些化合物大多数是手性分子，其不对称合成的挑战吸引了许多研究小组。特别是，通过插烯加成到3-亚烷基取代的羟吲哚（3亚烷基-1,3-二氢-2-创建手性中心的出羟吲哚环的ħ -吲哚-2-酮）已经出现在最近几年。这篇综述旨在对该主题进行概述。
1引言
2 Aldol和Mannich反应
3不饱和羰基化合物的添加
4硝基烯烃的添加
5其他
六，结论
吲哚代表许多天然产物中发现的一类重要的生物活性化合物和合成衍生物。这些化合物大多数是手性分子，其不对称合成的挑战吸引了许多研究小组。特别是，通过插烯加成到3-亚烷基取代的羟吲哚（3亚烷基-1,3-二氢-2-创建手性中心的出羟吲哚环的ħ -吲哚-2-酮）已经出现在最近几年。这篇综述旨在对该主题进行概述。
1引言
2 Aldol和Mannich反应
3不饱和羰基化合物的添加
4硝基烯烃的添加
5其他
六，结论
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