Poly(vinyl diaminotriazine): From Molecular Recognition to High‐Strength Hydrogels,Macromolecular Rapid Communications

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Poly(vinyl diaminotriazine): From Molecular Recognition to High‐Strength Hydrogels
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2018-05-28 , DOI: 10.1002/marc.201800190
Bo Liu ₁ , Wenguang Liu ₁

Affiliation

Poly(2‐vinyl‐4,6‐diamino‐1,3,5‐triazine), (PVDT) with diaminotriazine residues is found to form not only intramolecular hydrogen bonds, but also three robust, complementary hydrogen bonds with nucleobases such as thymine and uracil. Taking advantage of the three complementary hydrogen bonds, molecular recognition of a nucleic acid base has been investigated in previous work. Over the past few years, the use of PVDT has been extended to the construction of gene delivery vectors and nonswellable, high‐strength hydrogels by copolymerization with a hydrophilic monomer and/or crosslinker. In particular, many fascinating properties, such as excellent mechanical properties, stimuli responsiveness, the shape memory effect, and biodegradability, have emerged in PVDT‐based hydrogels. In this article, the molecular recognition and self‐assembly of diaminotriazine are introduced first, and then a particular focus is placed on the development of PVDT‐based high performance hydrogels, especially their biorelated applications.

中文翻译：

聚（乙烯基二氨基三嗪）：从分子识别到高强度水凝胶

发现具有二氨基三嗪残基的聚（2-乙烯基-4,6-二氨基-1,3,5-三嗪）（PVDT）不仅可以形成分子内氢键，还可以与胸腺嘧啶等核碱基形成三个牢固的互补氢键和尿嘧啶。利用三个互补氢键，核酸碱基的分子识别已在先前的工作中进行了研究。在过去的几年中，PVDT 的用途已扩展到通过与亲水单体和/或交联剂共聚来构建基因传递载体和不可膨胀的高强度水凝胶。特别是，基于 PVDT 的水凝胶出现了许多令人着迷的特性，例如优异的机械性能、刺激响应性、形状记忆效应和生物降解性。本文首先介绍了二氨基三嗪的分子识别和自组装，然后特别关注基于PVDT的高性能水凝胶的开发，特别是其生物相关应用。

更新日期：2018-05-28

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