Front Cover: Iridium‐Catalyzed Direct Asymmetric Alkylation of Aniline Derivatives using 2‐Norbornene (Asian J. Org. Chem. 6/2018),Asian Journal of Organic Chemistry

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Front Cover: Iridium‐Catalyzed Direct Asymmetric Alkylation of Aniline Derivatives using 2‐Norbornene (Asian J. Org. Chem. 6/2018)
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-05-24 , DOI: 10.1002/ajoc.201800261
Tomohiko Shirai ₁ , Takakazu Okamoto ₁ , Yasunori Yamamoto ₂

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Enantioselective transformations through the activation of C−H bond allows the facile synthesis of chiral building blocks. We developed an efficient and highly enantioselective direct alkylation process for acetanilides that use 2‐norbornene with a bis(phosphoramidite)‐cationic Ir catalytic system (up to 99% ee). This methodology allows the facile preparation of enantiomerically enriched exo‐2‐(bicyclo[2.2.1]heptan‐2‐yl)aniline, which can be readily transformed into other functionalities. More information can be found in the Communication by Tomohiko Shirai et al. on page 1054 in Issue 6, 2018 (DOI: 10.1002/ajoc.201800185).

中文翻译：

封面：使用2-降冰片烯进行铱催化的苯胺衍生物直接不对称烷基化（Asian J.Org.Chem.6 / 2018）

通过CH键的活化进行对映选择性转化，可以轻松合成手性结构单元。我们开发了一种高效且高度对映选择性的烷基苯胺直接烷基化方法，该方法将2-降冰片烯与双（亚磷酰胺）-阳离子Ir催化体系（ee高达99％）结合使用。这种方法可以轻松制备对映体富集的exo -2-（双环[2.2.1]庚烷-2-基）苯胺，可以很容易地将其转化为其他功能。有关更多信息，请参阅Shirai智彦等人的来文。就在第6期，2018 1054页（：10.1002 / ajoc.201800185 DOI）。

更新日期：2018-05-24

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