Obesity is one of the most serious global public health challenges of the 21st century. The aim of this study was to investigate the effects of dietary incorporation of açai seed flour (ASF) on lipid metabolism of high fat diet-induced obesity mice. C57BL/6 male mice were divided into four groups (n = 10): control group (C); high fat diet (HF); high fat diet with ASF (HFA15 and HFA30, high fat diet containing 15% or 30% ASF, respectively) for 12 weeks. Body composition, lipid metabolism and excretion, hepatic and adipose tissue morphology and biochemical parameters were assayed. The incorporation of 15% or 30% ASF in mice's diet promoted protective effect upon weight gain, prevented insulin resistance and improved lipid profile of animals, which had lower concentrations of glucose, insulin and leptin. Thus, ASF reduced lipogenesis preventing the development of fatty liver disease and hypertrophic obesity. It was also observed the influence of ASF consumption on the modulation of proteins involved with cholesterol synthesis and excretion. The high fecal weight in the ASF group demonstrates a significant action of the fibers in the excretion of bile acids and cholesterol. Biochemical parameters of the nutritional status were not altered nor were signs of toxicity observed in the animals with the ASF consumption, suggesting that the flour does not present toxic or harmful effects to the animals' health. The use of ASF prevents the development of obesity and its commorbidities, especially hepatic steatosis increasing cholesterol excretion.

肥胖是21世纪最严重的全球公共卫生挑战之一。这项研究的目的是调查膳食中掺入阿萨伊籽粉（ASF）对高脂饮食诱导的肥胖小鼠脂质代谢的影响。将C57BL / 6雄性小鼠分为四组（n = 10）：对照组（C）；对照组（C）。高脂饮食（HF）；使用ASF的高脂饮食（HFA15和HFA30，分别包含15％或30％ASF的高脂饮食）持续12周。测定了人体成分，脂质代谢和排泄，肝和脂肪组织的形态以及生化参数。在小鼠饮食中掺入15％或30％的ASF可以促进体重增加的保护作用，防止胰岛素抵抗并改善动物体内的脂质分布，这些动物的葡萄糖，胰岛素和瘦素的浓度较低。因此，ASF可减少脂肪生成，从而预防脂肪肝疾病和肥厚性肥胖症的发生。还观察到ASF消耗对胆固醇合成和排泄所涉及的蛋白质的调节的影响。ASF组的粪便重量很高，表明纤维在胆汁酸和胆固醇的排泄中具有重要作用。营养状态的生化参数没有改变，在食用ASF的动物中也未观察到毒性迹象，这表明面粉对动物的健康没有毒性或有害影响。使用ASF可防止肥胖症及其合并症的发展，尤其是肝脂肪变性会增加胆固醇的排泄。还观察到ASF消耗对胆固醇合成和排泄所涉及的蛋白质的调节的影响。ASF组的粪便重量很高，表明纤维在胆汁酸和胆固醇的排泄中具有重要作用。营养状态的生化参数没有改变，在食用ASF的动物中也未观察到毒性迹象，这表明面粉对动物的健康没有毒性或有害影响。使用ASF可防止肥胖症及其合并症的发展，尤其是肝脂肪变性会增加胆固醇的排泄。还观察到ASF消耗对胆固醇合成和排泄所涉及的蛋白质的调节的影响。ASF组的粪便重量很高，表明纤维在胆汁酸和胆固醇的排泄中具有重要作用。营养状态的生化参数没有改变，在食用ASF的动物中也未观察到毒性迹象，这表明面粉对动物的健康没有毒性或有害影响。使用ASF可防止肥胖症及其合并症的发展，尤其是肝脂肪变性会增加胆固醇的排泄。ASF组的粪便重量很高，表明纤维在胆汁酸和胆固醇的排泄中具有重要作用。营养状态的生化参数没有改变，在食用ASF的动物中也未观察到毒性迹象，这表明面粉对动物的健康没有毒性或有害影响。使用ASF可防止肥胖症及其合并症的发展，尤其是肝脂肪变性会增加胆固醇的排泄。ASF组的粪便重量很高，表明纤维在胆汁酸和胆固醇的排泄中具有重要作用。营养状态的生化参数没有改变，在食用ASF的动物中也未观察到毒性迹象，这表明面粉对动物的健康没有毒性或有害影响。ASF的使用可防止肥胖症及其合并症的发展，尤其是肝脂肪变性会增加胆固醇的排泄。