IgG1+ B cell immunity predates IgE responses in epicutaneous sensitization to foods,Allergy

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IgG1+ B cell immunity predates IgE responses in epicutaneous sensitization to foods
Allergy ( IF 12.6 ) Pub Date : 2018-10-11 , DOI: 10.1111/all.13481
R. Jiménez‐Saiz ₁ , Y. Ellenbogen ₁ , J. F. E. Koenig ₁ , M. E. Gordon ₁ , T. D. Walker ₁ , D. Rosace ₁ , P. Spill ₁ , K. Bruton ₁ , J. Kong ₁ , K. Monteiro ₁ , J. Wen ₁ , E. I. Tuomanen ₂ , R. Kolbeck ₃ , D. K. Chu ₄ , S. Waserman ₄ , M. Jordana ₁

Affiliation

The generation of IgE‐mediated food allergy in humans is silent and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remains to be elucidated. Here, we defined the evolution of allergen‐specific B‐cell responses during epicutaneous sensitization to foods.

中文翻译：

IgG1+ B 细胞免疫先于 IgE 反应，导致对食物的表皮过敏

人类 IgE 介导的食物过敏的产生是无声的，只有在出现临床症状时才能诊断出来。虽然实验模型已被用于研究过敏性致敏的一些机制，但体液免疫和记忆的产生仍有待阐明。在这里，我们定义了表皮对食物过敏期间过敏原特异性 B 细胞反应的演变。

更新日期：2018-10-11

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