Abstract Carboxymethyl cellulose (CMC)-based hydrogels have superabsorbent properties but low mechanical strength. Variation of other hydrogel components might improve the mechanical strength, but has been occasionally seen to decrease the swelling and drug-loading capacity. To address these problems, we designed a dual-component system, consisting of both carboxymethyl β-cyclodextrin (cmβCD) and CMC. We synthesized the hydrogels by crosslinking βCD or cmβCD with both cellulose (CEL) and CMC to evaluate their intrinsic mechanical strength and swelling capacity. The characteristic structure and morphology of each hydrogel was determined by Fourier- transform infrared spectroscopy, solid-state nuclear magnetic resonance spectroscopy, and field emission scanning electron microscopy. The storage modulus of the cmβCD/CMC gel was nearly eight-fold higher than that of the CMC gel only in rheology tests; the compressive strength was also enhanced while still retaining high swelling ability. We also investigated the drug-loading capacity and subsequent release properties, using tetracycline as a drug model. The cmβCD/CMC hydrogels showed the most effective tetracycline-loading capacity with the highest antibacterial activity among all hydrogels. They also showed the highest mechanical strength and the best drug release properties apart from the appreciable swelling capacity. Furthermore, cmβCD/CMC hydrogels are non-cytotoxic towards human dermal fibroblasts, suggesting their safe use as nontoxic, bio-friendly, and effective drug delivery systems.

中文翻译：

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含有羧甲基 β-环糊精的羧甲基纤维素基超吸收水凝胶可增强机械强度和有效的药物输送

摘要 羧甲基纤维素（CMC）基水凝胶具有高吸水性但机械强度低。其他水凝胶成分的变化可能会提高机械强度，但偶尔会降低溶胀和载药能力。为了解决这些问题，我们设计了一个双组分系统，由羧甲基 β-环糊精 (cmβCD) 和 CMC 组成。我们通过将 βCD 或 cmβCD 与纤维素 (CEL) 和 CMC 交联来合成水凝胶，以评估它们的内在机械强度和溶胀能力。通过傅里叶变换红外光谱、固态核磁共振光谱和场发射扫描电子显微镜确定每个水凝胶的特征结构和形态。cmβCD/CMC凝胶的储能模量仅在流变学测试中比CMC凝胶的储能模量高近8倍；抗压强度也有所提高，同时仍保持高溶胀能力。我们还使用四环素作为药物模型研究了载药能力和随后的释放特性。cmβCD/CMC 水凝胶在所有水凝胶中表现出最有效的四环素负载能力和最高的抗菌活性。除了可观的溶胀能力外，它们还显示出最高的机械强度和最佳的药物释放特性。此外，cmβCD/CMC 水凝胶对人真皮成纤维细胞无细胞毒性，表明它们可安全用作无毒、生物友好和有效的药物递送系统。抗压强度也有所提高，同时仍保持高溶胀能力。我们还使用四环素作为药物模型研究了载药能力和随后的释放特性。cmβCD/CMC 水凝胶在所有水凝胶中表现出最有效的四环素负载能力和最高的抗菌活性。除了可观的溶胀能力外，它们还显示出最高的机械强度和最佳的药物释放特性。此外，cmβCD/CMC 水凝胶对人真皮成纤维细胞无细胞毒性，表明它们可安全用作无毒、生物友好和有效的药物递送系统。抗压强度也有所提高，同时仍保持高溶胀能力。我们还使用四环素作为药物模型研究了载药能力和随后的释放特性。cmβCD/CMC 水凝胶在所有水凝胶中表现出最有效的四环素负载能力和最高的抗菌活性。除了可观的溶胀能力外，它们还显示出最高的机械强度和最佳的药物释放特性。此外，cmβCD/CMC 水凝胶对人真皮成纤维细胞无细胞毒性，表明它们可安全用作无毒、生物友好和有效的药物递送系统。cmβCD/CMC 水凝胶在所有水凝胶中表现出最有效的四环素负载能力和最高的抗菌活性。除了可观的溶胀能力外，它们还显示出最高的机械强度和最佳的药物释放特性。此外，cmβCD/CMC 水凝胶对人真皮成纤维细胞无细胞毒性，表明它们可安全用作无毒、生物友好和有效的药物递送系统。cmβCD/CMC 水凝胶在所有水凝胶中表现出最有效的四环素负载能力和最高的抗菌活性。除了可观的溶胀能力外，它们还显示出最高的机械强度和最佳的药物释放特性。此外，cmβCD/CMC 水凝胶对人真皮成纤维细胞无细胞毒性，表明它们可安全用作无毒、生物友好和有效的药物递送系统。