Nanoparticles can preferentially accumulate at sites of action and hold great promise to improve the therapeutic index of many drugs. While conventional methods of nanocarrier-mediated drug delivery have focused on primarily synthetic approaches, engineering strategies that combine synthetic nanoparticles with natural biomaterials have recently gained much attention. In particular, cell membrane-camouflaged nanoparticles are a new class of biomimetic nanoparticles that combine the unique functionalities of cellular membranes and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents. Herein, we report on the recent progress on cell membrane-coated nanoparticles for drug delivery. In particular, we highlight three areas: (i) prolonging systemic circulation via cell membrane coating, (ii) cell-specific targeting via cell membrane coating, and (iii) applications of cell membrane coating for drug delivery. The cell membrane-camouflaged nanoparticle platform has emerged as a novel delivery strategy with the potential to improve the therapeutic efficacy for the treatment of a variety of diseases.

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细胞膜伪装的纳米颗粒用于药物输送

纳米颗粒可以优先积聚在作用部位，并有望改善许多药物的治疗指数。尽管纳米载体介导的药物递送的常规方法主要集中在合成方法上，但是将合成纳米颗粒与天然生物材料结合起来的工程策略近来备受关注。特别地，被细胞膜伪装的纳米颗粒是一类新型的仿生纳米颗粒，其结合了细胞膜的独特功能和合成纳米材料的工程通用性，可有效递送治疗剂。在此，我们报道了用于药物递送的细胞膜包被的纳米颗粒的最新进展。特别是，我们强调了三个方面：（i）通过细胞膜涂层延长全身循环，（ii）通过细胞膜涂层的细胞特异性靶向，和（iii）细胞膜涂层在药物递送中的应用。细胞膜伪装的纳米颗粒平台已作为一种新型的递送策略出现，具有改善多种疾病的治疗功效的潜力。