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Functional optical coherence tomography of neurovascular coupling interactions in the retina
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2018-07-27 , DOI: 10.1002/jbio.201800089
Taeyoon Son 1 , Minhaj Alam 1 , Devrim Toslak 1, 2 , Benquan Wang 1 , Yiming Lu 1 , Xincheng Yao 1, 3
Affiliation  

Quantitative evaluation of retinal neurovascular coupling is essential for a better understanding of visual function and early detection of eye diseases. However, there is no established method to monitor coherent interactions between stimulus‐evoked neural activity and hemodynamic responses at high resolution. Here, we report a multimodal functional optical coherence tomography (OCT) imaging methodology to enable concurrent intrinsic optical signal (IOS) imaging of stimulus‐evoked neural activity and hemodynamic responses at capillary resolution. OCT angiography guided IOS analysis was used to separate neural‐IOS and hemodynamic‐IOS changes in the same retinal image sequence. Frequency flicker stimuli evoked neural‐IOS changes in the outer retina; that is, photoreceptor layer, first and then in the inner retina, including outer plexus layer (OPL), inner plexiform layer (IPL), and ganglion cell layer (GCL), which were followed by hemodynamic‐IOS changes primarily in the inner retina; that is, OPL, IPL, and GCL. Different time courses and signal magnitudes of hemodynamic‐IOS responses were observed in blood vessels with various diameters.

中文翻译:


视网膜神经血管耦合相互作用的功能光学相干断层扫描



视网膜神经血管耦合的定量评估对于更好地了解视觉功能和早期发现眼部疾病至关重要。然而,还没有既定的方法来以高分辨率监测刺激诱发的神经活动和血流动力学反应之间的连贯相互作用。在这里,我们报告了一种多模态功能光学相干断层扫描(OCT)成像方法,能够以毛细血管分辨率对刺激诱发的神经活动和血流动力学反应进行并发内在光信号(IOS)成像。 OCT 血管造影引导的 IOS 分析用于分离同一视网膜图像序列中的神经 IOS 和血流动力学 IOS 变化。频率闪烁刺激引起外视网膜神经-IOS 变化;即感光层,首先在视网膜内层,包括外丛层(OPL)、内丛状层(IPL)和神经节细胞层(GCL),随后主要在视网膜内层发生血流动力学-IOS变化;即 OPL、IPL 和 GCL。在不同直径的血管中观察到血流动力学-IOS 反应的不同时程和信号强度。
更新日期:2018-07-27
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