Bioengineering strategies to accelerate stem cell therapeutics,Nature

当前位置： X-MOL 学术 › Nature › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bioengineering strategies to accelerate stem cell therapeutics
Nature ( IF 50.5 ) Pub Date : 2018-05-01 , DOI: 10.1038/s41586-018-0089-z
Christopher M Madl ₁ , Sarah C Heilshorn ₂ , Helen M Blau ₁

Affiliation

Although only a few stem cell-based therapies are currently available to patients, stem cells hold tremendous regenerative potential, and several exciting clinical applications are on the horizon. Biomaterials with tuneable mechanical and biochemical properties can preserve stem cell function in culture, enhance survival of transplanted cells and guide tissue regeneration. Rapid progress with three-dimensional hydrogel culture platforms provides the opportunity to grow patient-specific organoids, and has led to the discovery of drugs that stimulate endogenous tissue-specific stem cells and enabled screens for drugs to treat disease. Therefore, bioengineering technologies are poised to overcome current bottlenecks and revolutionize the field of regenerative medicine.

中文翻译：

加速干细胞治疗的生物工程策略

尽管目前只有少数基于干细胞的疗法可供患者使用，但干细胞具有巨大的再生潜力，并且一些令人兴奋的临床应用即将出现。具有可调节机械和生化特性的生物材料可以在培养物中保留干细胞功能，提高移植细胞的存活率并引导组织再生。三维水凝胶培养平台的快速进展为培养患者特异性类器官提供了机会，并导致了刺激内源性组织特异性干细胞的药物的发现，并使得筛选治疗疾病的药物成为可能。因此，生物工程技术有望克服当前的瓶颈并彻底改变再生医学领域。

更新日期：2018-05-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南