Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions,Synlett

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Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions
Synlett ( IF 1.7 ) Pub Date : 2018-05-16 , DOI: 10.1055/s-0037-1610126
Jianxian Gong ₁ , Zhen Yang _{1,

2} , Yueqing Gu ₁ , Ceheng Tan ₁

Affiliation

This account describes our group’s latest research in the field of diversity-oriented synthesis of natural products via gold-catalyzed cascade reactions. We present two general strategies based on gold-catalyzed cycloisomerization: a gold-catalyzed cascade reaction of 1,7-diynes and a pinacol-terminated gold-catalyzed cascade reaction. We highlight our development of synthetic methods for the construction of biologically active natural products by using these two strategies. 1 Introduction 2 Gold-Catalyzed Cascade Reactions of 1,7-Diynes 2.1 Collective Synthesis of C15 Oxygenated Drimane-Type Sesquiterpenoids 2.2 Synthesis of Left-Wing Fragment of Azadirachtin I 2.3 Collective Synthesis of Cladiellins 3 Pinacol-Terminated Gold-Catalyzed Cascade Reaction 3.1 Asymmetric Formal Total Synthesis of (+)-Cortistatins 3.2 Total Synthesis of Orientalol F 3.3 Asymmetric Total Synthesis of (–)-Farnesiferol C 4 Summary and Outlook

中文翻译：

通过金催化级联反应以多样性为导向合成天然产物

该帐户描述了我们小组在通过金催化级联反应以多样性为导向的天然产物合成领域的最新研究。我们提出了两种基于金催化环异构化的一般策略：1,7-二炔的金催化级联反应和频哪醇终止的金催化级联反应。我们重点介绍了通过使用这两种策略构建具有生物活性的天然产品的合成方法的发展。1 引言 2 金催化的 1,7-二炔的级联反应 2.1 C15 氧化 Drimane 型倍半萜类化合物的集体合成 2.2 印楝素 I 左翼片段的合成 2.3 Cladiellins 的集体合成 3 Cascade-Caladiellins-Calcadelyzed Responsible 3. (+)-皮质抑素的正式全合成 3.2 东方醇 F 3 的全合成。

更新日期：2018-05-16

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