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Stellatolide H, a cytotoxic peptide lactone from a deep-sea sponge Discodermia sp.
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-05-15 , DOI: 10.1016/j.tetlet.2018.05.033 Shohei Nakamukai , Kentaro Takada , Kazuo Furihata , Yuji Ise , Shigeru Okada , Yasuhiro Morii , Nobuhiro Yamawaki , Tomohiro Takatani , Osamu Arakawa , Kirk R. Gustafson , Shigeki Matsunaga
中文翻译:
Stellatolide H,一种来自深海海绵Discodermia sp。的细胞毒性肽内酯。
更新日期:2018-05-15
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-05-15 , DOI: 10.1016/j.tetlet.2018.05.033 Shohei Nakamukai , Kentaro Takada , Kazuo Furihata , Yuji Ise , Shigeru Okada , Yasuhiro Morii , Nobuhiro Yamawaki , Tomohiro Takatani , Osamu Arakawa , Kirk R. Gustafson , Shigeki Matsunaga
Stellatolide H (1) was isolated from a deep-sea sponge Discodermia sp. as the cytotoxic constituent. The planar structure of 1 was elucidated on the basis of the NMR spectroscopic and mass spectrometric data. The absolute configurations of the constituent amino acid residues were determined by the Marfey’s method. Stellatolide H (1) is a peptide lactone of the callipeltin class with its N-terminus blocked by 3-hydroxy-6,8-dimethyldeca-(4Z,6E)-dienoic acid (Hdda).
中文翻译:
Stellatolide H,一种来自深海海绵Discodermia sp。的细胞毒性肽内酯。
从深海海绵Discodermia sp。分离出Stellatolide H(1)。作为细胞毒性成分。根据NMR光谱和质谱数据阐明了1的平面结构。组成氨基酸残基的绝对构型通过Marfey方法确定。Stellatolide H(1)是Callipeltin类的肽内酯,其N端被3-羟基-6,8-二甲基癸基-(4 Z,6 E)-二烯酸(Hdda)封闭。