Abstract The paper presents the effect of polymer solution composition on the morphology, mechanical properties and drug permeability of the asymmetric polyamide 6 (PA6) membranes prepared by immersion precipitation. The effect of polymer solution composition on morphology, mechanical properties and permeability of the produced membrane is considered, since these properties are of relevance for drug delivery applications. PA6-formic acid-deionized water solutions were used to prepare membranes for further characterization with differential scanning calorimetry and scanning electron microscopy for morphology analysis, tensile testing and drug permeability tests. The results show that the amount of PA6 does not significantly affect morphology of the membrane, while having pronounced effect on tensile elastic modulus (50% increase). On the other hand, the concentration of formic acid in solution (dissolution intensity) influences crystallization dynamics and significantly changes the morphology of membrane (in the range of approximately 75–100 wt% of formic acid concentrations), consequently having effect on drug permeability.

中文翻译：

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PA6-甲酸-水体系浸渍沉淀法制备的PA6膜的力学性能和药物渗透性

摘要 本文介绍了聚合物溶液组成对浸渍法制备的不对称聚酰胺 6 (PA6) 膜的形态、力学性能和药物渗透性的影响。考虑了聚合物溶液组成对所生产膜的形态、机械性能和渗透性的影响，因为这些性能与药物递送应用相关。PA6-甲酸-去离子水溶液用于制备膜，用于通过差示扫描量热法和扫描电子显微镜进一步表征，用于形态分析、拉伸测试和药物渗透性测试。结果表明，PA6 的用量对膜的形态没有显着影响，而对拉伸弹性模量有显着影响（增加 50%）。另一方面，