Regioselective Synthesis and Antibacterial Activity Studies of 1,2,3‐Triazol‐4‐YL]‐4‐methyl‐2H‐chromen‐2‐ones,Journal of Heterocyclic Chemistry

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Regioselective Synthesis and Antibacterial Activity Studies of 1,2,3‐Triazol‐4‐YL]‐4‐methyl‐2H‐chromen‐2‐ones
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2018-05-08 , DOI: 10.1002/jhet.3175
Niranjan Kolichala ₁ , Bhupalreddy Thummala ₂ , Vasantha Kumar Pai Karkala ₃

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Synthesis, spectral analysis, and antibacterial activity of new coumarin derivatives are described in this paper. Twelve new coumarin derivatives were synthesized in moderate to good yields by the react with 4‐methyl‐6‐(prop‐2‐ynyloxy)‐2H‐chromen‐2‐one (3a–c) and ethyl azide (4a–l) and done by the click reaction to obtained 6‐[(l‐ethyl‐lH‐l,2,3‐triazol‐4‐yl)methoxy]‐4‐methyl‐2H‐chromen‐2‐ones (5a–l). The structures of all the newly synthesized molecules were assigned by elemental analysis and spectral data. The synthesized compounds were screened for their antibacterial activities strains using Cup plate method.

中文翻译：

1,2,3-三唑-4-基] -4-甲基-2H-铬-2-基团的区域选择性合成和抗菌活性研究

本文介绍了新香豆素衍生物的合成，光谱分析和抗菌活性。通过与4-甲基-6-（prop-2-炔氧基）-2- H-铬原子-2-酮（3a – c）和叠氮化乙酯（4a – l）反应，合成了十二种新的香豆素衍生物，具有中等至良好的产率。并且通过点击反应至得到的6-完成- [（1-乙基-1- ħ -1,2,3-三唑-4-基）甲氧基] -4-甲基-2- ħ -色烯-2-酮（5A -升）。通过元素分析和光谱数据确定所有新合成的分子的结构。使用杯板法筛选合成的化合物的抗菌活性菌株。

更新日期：2018-05-08

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