Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana,Journal of Natural Products

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Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-05-10 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00170
Joanne Soon-Yee Yeap , Suerialoasan Navanesan , Kae-Shin Sim , Kien-Thai Yong , Subramaniam Gurusamy ₁ , Siew-Huah Lim , Yun-Yee Low , Toh-Seok Kam

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Examination of the EtOH extract of the Malayan Alstonia penangiana resulted in the isolation of 10 new alkaloids, comprising two ajmaline (1, 2), four macroline oxindole (3–6), and four macroline–akuammiline bisindole alkaloids (7–10). The structures of these alkaloids were determined based on analysis of the spectroscopic data and, in the case of the oxindole 6 and the bisindole alkaloid 7, also confirmed by X-ray diffraction analysis. The bisindole alkaloids 7 and 8 showed pronounced in vitro growth inhibitory activity against an array of human cancer cell lines, including KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, HCT 116, and A549 cells with IC₅₀ values in the 0.3–8.3 μM range.

中文翻译：

阿义马林，羟吲哚，和细胞毒性Macroline-Akuammiline双吲哚生物碱灯台penangiana

马来亚的乙醇提取物的检查鸡骨常山penangiana导致了10种新生物碱的分离，包括两个阿义马林（1，2），四个macroline羟吲哚（3 - 6），和四个macroline-akuammiline双吲哚生物碱（7 - 10）。这些生物碱的结构基于光谱数据的分析来确定，并且在羟吲哚6和双吲哚生物碱7的情况下，也通过X射线衍射分析来确认。双吲哚生物碱7和8对具有IC的人类癌细胞系（包括KB，长春新碱抗性KB，PC-3，LNCaP，MCF7，MDA-MB-231，HT-29，HCT 116和A549细胞）显示出明显的体外生长抑制活性在0.3–8.3μM范围内的_50个值。

更新日期：2018-05-10

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