The evolutionarily conserved Hippo pathway is a key regulator of organ size and tissue homeostasis. Its dysregulation is linked to multiple pathological disorders. In addition to regulating development and growth, recent studies show that Hippo pathway components such as MST1/2 and LATS1/2 kinases, as well as YAP/TAZ transcriptional coactivators, are regulated by metabolic pathways and that the Hippo pathway controls metabolic processes at the cellular and organismal levels in physiological and metabolic disease states such as obesity, type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), cardiovascular disorders, and cancer. In this review we summarize the connection between key Hippo components and metabolism, and how this interplay regulates cellular metabolism and metabolic pathways. The emerging function of Hippo in the regulation of metabolic homeostasis under physiological and pathological conditions is highlighted.

中文翻译：

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河马信号：细胞和全身代谢的关键新兴途径

进化上保守的 Hippo 通路是器官大小和组织稳态的关键调节器。它的失调与多种病理疾病有关。除了调节发育和生长外，最近的研究表明，Hippo 通路组分，如 MST1/2 和 LATS1/2 激酶，以及 YAP/TAZ 转录共激活因子，受代谢通路调节，并且 Hippo 通路控制代谢过程。肥胖、2 型糖尿病 (T2D)、非酒精性脂肪性肝病 (NAFLD)、心血管疾病和癌症等生理和代谢疾病状态下的细胞和生物体水平。在这篇综述中，我们总结了关键 Hippo 成分与代谢之间的联系，以及这种相互作用如何调节细胞代谢和代谢途径。