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Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing
ACS Omega ( IF 3.7 ) Pub Date : 2018-05-01 00:00:00 , DOI: 10.1021/acsomega.8b00308 Yueyuan Zheng 1 , Yuqing Liang 1 , Depan Zhang 1 , Xiaoyi Sun 1 , Li Liang 2 , Juan Li 1 , You-Nian Liu 1
ACS Omega ( IF 3.7 ) Pub Date : 2018-05-01 00:00:00 , DOI: 10.1021/acsomega.8b00308 Yueyuan Zheng 1 , Yuqing Liang 1 , Depan Zhang 1 , Xiaoyi Sun 1 , Li Liang 2 , Juan Li 1 , You-Nian Liu 1
Affiliation
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Injectable scaffolds are of great interests for skin regeneration because they can fill irregularly shaped defects through minimally invasive surgical treatments. In this study, an injectable hydrogel from biopolymers is developed and its application as wound dressings is examined. Gelatin-based hydrogels were successfully prepared at body temperature upon blending with low content of gellan, and the synergetic effect on the gel formation was carefully characterized through rheological methods. The electrostatic complexation between gelatin and gellan was confirmed to contribute a continuous hydrogel network. The obtained blend hydrogel demonstrates remarkable shear-thinning and self-recovering properties. For antibacterial purpose, tannic acid was incorporated into the blend hydrogel. In addition, tannic acid-loaded blend hydrogel was verified to accelerate the wound healing on the mice model, significantly than the control groups. Thus, this paper presents a facile approach without chemical modification to construct injectable gelatin-based hydrogels, which have great potential as a wound dressing or tissue scaffold at body temperature.
中文翻译：
与结冷胶混合的明胶基水凝胶作为可注射伤口敷料
可注射支架对于皮肤再生具有很大的意义，因为它们可以通过微创手术治疗来填充不规则形状的缺损。在这项研究中，开发了一种由生物聚合物制成的可注射水凝胶，并检查了其作为伤口敷料的应用。与低含量结冷胶混合后，在体温下成功制备了明胶基水凝胶，并通过流变学方法仔细表征了对凝胶形成的协同效应。明胶和结冷胶之间的静电络合被证实有助于形成连续的水凝胶网络。所得共混水凝胶表现出显着的剪切稀化和自我恢复性能。为了抗菌目的，将单宁酸加入到混合水凝胶中。此外，经证实，负载单宁酸的混合水凝胶可以加速小鼠模型的伤口愈合，显着高于对照组。因此，本文提出了一种无需化学修饰的简便方法来构建可注射的明胶基水凝胶，该水凝胶作为体温下的伤口敷料或组织支架具有巨大的潜力。
更新日期：2018-05-01
中文翻译：
与结冷胶混合的明胶基水凝胶作为可注射伤口敷料
可注射支架对于皮肤再生具有很大的意义，因为它们可以通过微创手术治疗来填充不规则形状的缺损。在这项研究中，开发了一种由生物聚合物制成的可注射水凝胶，并检查了其作为伤口敷料的应用。与低含量结冷胶混合后，在体温下成功制备了明胶基水凝胶，并通过流变学方法仔细表征了对凝胶形成的协同效应。明胶和结冷胶之间的静电络合被证实有助于形成连续的水凝胶网络。所得共混水凝胶表现出显着的剪切稀化和自我恢复性能。为了抗菌目的，将单宁酸加入到混合水凝胶中。此外，经证实，负载单宁酸的混合水凝胶可以加速小鼠模型的伤口愈合，显着高于对照组。因此，本文提出了一种无需化学修饰的简便方法来构建可注射的明胶基水凝胶，该水凝胶作为体温下的伤口敷料或组织支架具有巨大的潜力。
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