Patterned Arrays of Supramolecular Microcapsules,Advanced Functional Materials

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Patterned Arrays of Supramolecular Microcapsules
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-03-30 , DOI: 10.1002/adfm.201800550
Jing Zhang _{1,

2} , Ji Liu ₃ , Ziyi Yu ₁ , Su Chen ₂ , Oren A. Scherman ₃ , Chris Abell ₁

Affiliation

Micropatterning of hydrogel has brought innovative outcomes in fundamental and applied material sciences. Previous approaches have mainly been dedicated to fabricate arrays of bulk hydrogel beads, which have inherent challenges including loading ability, scalability, specificity, and versatility. Here, a methodology is presented to create hollow microcapsule arrays from sessile microdroplets. The difference in wettability between hydrophilic and hydrophobic surfaces enables self‐partitioning of liquid into microdroplet arrays, serving as microreservoirs to load complementarily functionalized host–guest polymers, cucurbit[8]uril‐threaded highly branched polyrotaxanes (HBP‐CB[8]) and naphthyl‐functionalized hydroxyethyl cellulose (HEC‐Np). The interfacial dynamic complexation between positively charged HBP‐CB[8] and HEC‐Np occurs in the presence of negatively charged surfactants, resulting in condensed supramolecular hydrogel skins. The hydrogel microcapsules are uniform in size and are developed to encapsulate target cargos in a robust and well‐defined manner. Moreover, the microcapsule substrates are further used for surface enhanced Raman spectroscopy sensing upon loading of gold nanoparticles. This facile assembly of microcapsule arrays has potential applications in controlled cargo delivery, bio‐sensing, high‐throughput analysis, and sorting.

中文翻译：

超分子微胶囊的图案化阵列

水凝胶的微图案化在基础和应用材料科学中带来了创新成果。先前的方法主要致力于制造散装水凝胶珠粒的阵列，其具有固有的挑战，包括负载能力，可扩展性，特异性和多功能性。在这里，提出了一种方法从无柄微滴创建空心微胶囊阵列。亲水性表面和疏水性表面之间的可湿性差异使液体能够自我分配成微滴阵列，从而充当微储器，以装载互补功能化的主客体聚合物，葫芦[8]尿螺纹高支链聚轮烷（HBP-CB [8]）和萘基官能化的羟乙基纤维素（HEC-Np）。带正电的HBP-CB [8]和HEC-Np之间的界面动态络合发生在带负电的表面活性剂的存在下，导致超分子水凝胶皮肤凝结。水凝胶微胶囊的大小均一，并且以稳健且定义明确的方式囊封了目标货物。此外，微胶囊基质还用于在负载金纳米颗粒时的表面增强拉曼光谱感测。这种微胶囊阵列的简便组装在控制货物运输，生物传感，高通量分析和分类方面具有潜在的应用。微胶囊基质进一步用于在金纳米颗粒加载后进行表面增强拉曼光谱检测。这种微胶囊阵列的简便组装在控制货物运输，生物传感，高通量分析和分类方面具有潜在的应用。微胶囊基质进一步用于在金纳米颗粒加载后进行表面增强拉曼光谱检测。这种微胶囊阵列的简便组装在控制货物运输，生物传感，高通量分析和分类方面具有潜在的应用。

更新日期：2018-03-30

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