An Injectable Supramolecular Polymer Nanocomposite Hydrogel for Prevention of Breast Cancer Recurrence with Theranostic and Mammoplastic Functions,Advanced Functional Materials

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An Injectable Supramolecular Polymer Nanocomposite Hydrogel for Prevention of Breast Cancer Recurrence with Theranostic and Mammoplastic Functions
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-04-14 , DOI: 10.1002/adfm.201801000
Yuanhao Wu ₁ , Hongbo Wang ₁ , Fei Gao ₁ , Ziyang Xu ₁ , Fengying Dai ₂ , Wenguang Liu ₁

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The high locoregional breast cancer recurrence rate poses a significant risk for patients' survival. Injecting theranostic drugs‐laden soft tissue‐like hydrogels into the resected breast cavity is a promising strategy to achieve both precisely local therapy of breast cancer and reconstructive mammoplasty. In this work, a robust injectable thermoresponsive supramolecular poly(N‐acryloyl glycinamide‐co‐acrylamide) (PNAm) hydrogel bearing polydopamine (PDA) coated‐gold nanoparticles (AuNPs) and doxorubicin (DOX) is fabricated. The supramolecular polymer nanocomposite (SPN) hydrogels exhibit an excellent photothermal effect arising from PDA‐AuNPs that are tightly fixed to the hydrogel matrix via PDA and amide moieties in the network, built‐in near infrared (NIR) light‐triggered gel–sol transition as well as tunable drug delivery. The PNAm‐PDAAu‐DOX sol driven by prior heating is injected into the cavity of resected cancerous breasts of rats where gelation occurred rapidly while the temperature decreased to body temperature, thereby finely serving as a breast filler. During 4 week of implantation, interval NIR light irradiation can mediate photothermal effect and concertedly controllable DOX release, thus collectively preventing the recurrence of breast cancer. Remarkably, this stable remoldable SPN hydrogel facilitates the breast reconstruction and can be tracked by computed tomography (CT) imaging owing to the intrinsic X‐ray attenuation property of the loaded AuNPs.

中文翻译：

可注射的超分子聚合物纳米复合水凝胶，用于预防具有治疗和乳腺功能的乳腺癌复发

局部乳腺癌高复发率对患者的生存构成重大风险。将切除肿瘤的载有治疗药物的软组织样水凝胶注入切除的乳腺腔内是一种有前途的策略，既可以实现乳腺癌的精确局部治疗，又可以进行乳房再造术。在这项工作中，一个强大的可注射温敏超分子聚（ñ -丙烯glycinamide-合作制备了带有聚多巴胺（PDA）涂层金纳米颗粒（AuNPs）和阿霉素（DOX）的丙烯酰胺（PNAm）水凝胶。超分子聚合物纳米复合物（SPN）水凝胶表现出出色的光热效应，这是由于PDA-AuNP通过PDA和网络中的酰胺基团牢固地固定在水凝胶基质上，内置了近红外（NIR）光触发的凝胶-溶胶转变以及可调式药物输送。将事先加热驱动的PNAm-PDAAu-DOX溶胶注入已切除的大鼠癌性乳腺腔中，在该腔中胶凝迅速发生，而温度降低至体温，从而很好地充当了乳腺填充物。在植入的4周内，间歇性NIR光照射可以介导光热效应并协调地控制DOX的释放，从而共同预防乳腺癌的复发。值得注意的是，这种稳定的可重塑SPN水凝胶有利于乳房重建，并且由于加载的AuNP的固有X射线衰减特性，可以通过计算机断层扫描（CT）成像进行跟踪。

更新日期：2018-04-14

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