Silylation of Aryl Halides with Monoorganosilanes Activated by Lithium Alkoxide,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Silylation of Aryl Halides with Monoorganosilanes Activated by Lithium Alkoxide
Organic Letters ( IF 4.9 ) Pub Date : 2018-05-01 00:00:00 , DOI: 10.1021/acs.orglett.8b00818
Takumi Yoshida ₁ , Laurean Ilies ₁ , Eiichi Nakamura ₁

Affiliation

Lithium alkoxide activates a monoorganosilane to generate a transient LiH/alkoxysilane complex, which quickly reacts with aryl and alkenyl halides at 25 °C to deliver a diorganosilane product. Experimental and theoretical studies suggest that the reaction includes nucleophilic attack of LiH on the halogen atom of the organic halide to generate a transient organolithium/alkoxysilane intermediate, which undergoes quick carbon–silicon bond formation within the complex.

中文翻译：

芳基卤化物与烷氧基锂活化的单有机硅烷硅烷化

烷氧基锂激活单有机硅烷，生成瞬态LiH /烷氧基硅烷络合物，该络合物在25°C时与芳基卤化物和烯基卤化物快速反应，生成二有机硅烷产物。实验和理论研究表明，该反应包括LiH对有机卤化物的卤素原子的亲核攻击，从而生成瞬态有机锂/烷氧基硅烷中间体，该中间体在配合物中迅速形成碳-硅键。

更新日期：2018-05-01

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南