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Synthesis of Indolo[1,2‐b]isoquinoline Derivatives by Lewis Acid‐Catalyzed Intramolecular Friedel–Crafts Alkylation Reaction
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-05-28 , DOI: 10.1002/ejoc.201800162
Jitendra Gour 1 , Srikanth Gatadi 1 , Atulya Nagarsenkar 1 , Bathini Nagendra Babu 1 , Y. V. Madhavi 1 , Srinivas Nanduri 1
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-05-28 , DOI: 10.1002/ejoc.201800162
Jitendra Gour 1 , Srikanth Gatadi 1 , Atulya Nagarsenkar 1 , Bathini Nagendra Babu 1 , Y. V. Madhavi 1 , Srinivas Nanduri 1
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Synthesis of indolo[1,2‐b]isoquinoline derivatives by Lewis acid‐catalyzed intramolecular Friedel–Crafts alkylation reaction of 2‐indolylmethanols is reported. The reaction proceeds well with both secondary and primary 2‐indolylmethanols. The method efficiently affords polycyclic fused indole derivatives in moderate to high yields with good functional group tolerance.
中文翻译：
Lewis酸催化的分子内Friedel-Crafts烷基化反应合成吲哚[1,2-b]异喹啉衍生物
据报道，路易斯酸催化的2-吲哚基甲醇的分子内Friedel-Crafts烷基化反应合成了吲哚[1,2- b ]异喹啉衍生物。该反应在仲和仲2-吲哚基甲醇中均能很好地进行。该方法以中等至高产率有效地提供具有良好官能团耐受性的多环稠合吲哚衍生物。
更新日期：2018-05-28
中文翻译：
Lewis酸催化的分子内Friedel-Crafts烷基化反应合成吲哚[1,2-b]异喹啉衍生物
据报道，路易斯酸催化的2-吲哚基甲醇的分子内Friedel-Crafts烷基化反应合成了吲哚[1,2- b ]异喹啉衍生物。该反应在仲和仲2-吲哚基甲醇中均能很好地进行。该方法以中等至高产率有效地提供具有良好官能团耐受性的多环稠合吲哚衍生物。
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