Synthesis of Bi(hetero)aryls via Sequential Oxidation and Decarboxylation of Benzylamines in a Batch/Fully Automated Continuous Flow Process,European Journal of Organic Chemistry

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Synthesis of Bi(hetero)aryls via Sequential Oxidation and Decarboxylation of Benzylamines in a Batch/Fully Automated Continuous Flow Process
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-06-01 , DOI: 10.1002/ejoc.201800223
Bhushan Mahajan ₁ , Dnyaneshwar Aand ₁ , Ajay K. Singh ₁

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Herein we report the first protocol for synthesis of biaryls and bi(hetero)aryls via sequential oxidation and decarboxylation of benzylamines in a batch/fully automated continuous flow process. Since the batch reaction is less safe, we have chosen a convincing automated flow‐setup to perform it in a controlled and safe manner one‐pot synthesis of biaryls and bi(hetero)aryls.

中文翻译：

分批/全自动连续流工艺中通过苄胺的顺序氧化和脱羧合成双（杂）芳基

在这里，我们报告了在批处理/全自动连续流工艺中通过顺序氧化和苄基胺脱羧合成联芳基和联（杂）芳基的第一个协议。由于分批反应的安全性较低，因此我们选择了令人信服的自动流程设置，以受控且安全的方式进行联芳基和联（杂）芳基的一锅法合成。

更新日期：2018-06-01

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