In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, the fixation approaches onto the tissue through suture or phototriggered reaction inevitably cause new tissue damage. Herein, a paintable hydrogel is constructed based on Fe³⁺‐triggered simultaneous polymerization of covalently linked pyrrole and dopamine in the hyperbranched chains where the in situ formed conductive polypyrrole also uniquely serves to crosslink network. This conductive and adhesive hydrogel can be conveniently painted as a patch onto the heart surface without adverse liquid leakage. The functional patch whose conductivity is equivalent to that of normal myocardium is strongly bonded to the beating heart within 4 weeks, accordingly efficiently boosting the transmission of electrophysiological signals. Eventually, the reconstruction of cardiac function and revascularization of the infarct myocardium are remarkably improved. The translatable suture‐free strategy reported in this work is promising to address the human clinical challenges in cardiac tissue engineering.

中文翻译：

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可喷涂和可快速粘合的导电水凝胶，可作为治疗性心脏修补剂

近年来，已经开发出用于治疗心肌梗塞的心脏贴剂。然而，通过缝合或光触发反应将固定物固定到组织上不可避免地引起新的组织损伤。在此，基于Fe ³⁺构建了可绘画的水凝胶在超支链中触发共价连接的吡咯和多巴胺的同时聚合，在该处原位形成的导电聚吡咯也独特地起到交联网络的作用。这种导电性和粘合性水凝胶可以方便地以贴剂的形式涂在心脏表面上，而不会造成不利的液体泄漏。其电导率等同于正常心肌的功能性贴片在4周内牢固地与跳动的心脏结合，从而有效地增强了电生理信号的传输。最终，显着改善了心功能的重建和梗死心肌的血运重建。这项工作中报道的可翻译无缝合策略有望解决心脏组织工程中的人类临床挑战。