Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance,ACS Nano

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Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance
ACS Nano ( IF 15.8 ) Pub Date : 2015-12-02 00:00:00 , DOI: 10.1021/acsnano.5b05999
Marc P Kai ₁ , Hailey E Brighton , Catherine A Fromen ₁ , Tammy W Shen , J Christopher Luft , Yancey E Luft , Amanda W Keeler , Gregory R Robbins , Jenny P Y Ting , William C Zamboni , James E Bear , Joseph M DeSimone ₁

Affiliation

Long-circulating nanoparticles are essential for increasing tumor accumulation to provide therapeutic efficacy. While it is known that tumor presence can alter the immune system, very few studies have explored this impact on nanoparticle circulation. In this report, we demonstrate how the presence of a tumor can change the local and global immune system, which dramatically increases particle clearance. We found that tumor presence significantly increased clearance of PRINT hydrogel nanoparticles from the circulation, resulting in increased accumulation in the liver and spleen, due to an increase in M2-like macrophages. Our findings highlight the need to better understand interactions between immune status and nanoparticle clearance, and suggest that further consideration of immune function is required for success in preclinical and clinical nanoparticle studies.

中文翻译：

肿瘤的存在会引起整体免疫变化并增强纳米颗粒的清除

长循环纳米颗粒对于增加肿瘤积累以提供治疗效果至关重要。虽然众所周知肿瘤的存在可以改变免疫系统，但很少有研究探讨这种对纳米颗粒循环的影响。在这份报告中，我们展示了肿瘤的存在如何改变局部和整体免疫系统，从而显着提高颗粒清除率。我们发现，肿瘤的存在显着增加了 PRINT 水凝胶纳米颗粒从循环中的清除率，由于 M2 样巨噬细胞的增加，导致肝脏和脾脏中的积累增加。我们的研究结果强调需要更好地了解免疫状态和纳米颗粒清除之间的相互作用，并表明需要进一步考虑免疫功能才能在临床前和临床纳米颗粒研究中取得成功。

更新日期：2015-12-02

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