Type I Collagen-Derived Injectable Conductive Hydrogel Scaffolds as Glucose Sensors,ACS Applied Materials & Interfaces

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Type I Collagen-Derived Injectable Conductive Hydrogel Scaffolds as Glucose Sensors
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-27 00:00:00 , DOI: 10.1021/acsami.8b04091
Ranjithkumar Ravichandran ₁ , Jose G. Martinez ₁ , Edwin W. H. Jager ₁ , Jaywant Phopase _{1,

2} , Anthony P. F. Turner ₁

Affiliation

The advent of home blood glucose monitoring revolutionized diabetes management, and the recent introduction of both wearable devices and closed-loop continuous systems has enormously impacted the lives of people with diabetes. We describe the first fully injectable soft electrochemical glucose sensor for in situ monitoring. Collagen, the main component of a native extracellular matrix in humans and animals, was used to fabricate an in situ gellable self-supporting electroconductive hydrogel that can be injected onto an electrode surface or into porcine meat to detect glucose amperometrically. The study provides a proof-of-principle of an injectable electrochemical sensor suitable for monitoring tissue glucose levels that may, with further development, prove clinically useful in the future.

中文翻译：

I型胶原衍生的可注射导电水凝胶支架作为葡萄糖传感器。

家用血糖监测的出现彻底改变了糖尿病的管理方法，最近可穿戴设备和闭环连续系统的引入极大地影响了糖尿病患者的生活。我们描述了第一个用于现场监测的完全可注射的软电化学葡萄糖传感器。胶原蛋白是人类和动物体内天然细胞外基质的主要成分，被用于制造原位可胶凝的自支撑导电水凝胶，该凝胶可注入电极表面或猪肉中，以安培方式检测葡萄糖。这项研究提供了适用于监测组织葡萄糖水平的可注射电化学传感器的原理证明，随着进一步的发展，将来可能在临床上被证明是有用的。

更新日期：2018-04-27

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