A type of pyridinium-decorated 1,4-pentadien-3-one derivatives possessing flexible alkyls were designed and synthesized by integrating the key scaffolds of pyridinium cations and 1,4-pentadien-3-one skeleton in a single molecular architecture. Antimicrobial bioassays indicated that some of the target molecules exerted considerable bioactivities against six phytopathogenic strains, especially for Xanthomonas oryzae pv. oryzae, the minimal EC₅₀ value can reach to 0.504 µg/mL. A plausible action mechanism for this kind of compounds was proposed and confirmed by employing fluorescent spectroscopy, fluorescence microscopy, and scanning electron microscopy. We anticipated that this finding can promote high-efficient lead compounds discovery in the research of antimicrobial chemotherapy.

通过将吡啶鎓阳离子的关键骨架和1,4-戊二烯-3-one骨架整合在一个分子结构中，设计并合成了一种具有柔性烷基的吡啶鎓修饰的1,4-戊二烯-3-酮衍生物。抗菌生物测定表明，某些靶分子对六种植物致病菌株具有相当大的生物活性，特别是对于米氏黄单胞菌。米曲霉，最小EC ₅₀值可以达到0.504 µg / mL。提出了这种化合物的合理作用机理，并通过荧光光谱，荧光显微镜和扫描电子显微镜进行了证实。我们预期该发现可以促进抗菌化学研究中高效铅化合物的发现。