Encapsulation of Curcumin Nanoparticles with MMP9-Responsive and Thermos-Sensitive Hydrogel Improves Diabetic Wound Healing,ACS Applied Materials & Interfaces

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Encapsulation of Curcumin Nanoparticles with MMP9-Responsive and Thermos-Sensitive Hydrogel Improves Diabetic Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-24 00:00:00 , DOI: 10.1021/acsami.8b03868
Juan Liu ₁ , Zhiqiang Chen ₁ , Jie Wang ₁ , Ruihong Li ₁ , Tingting Li ₁ , Mingyang Chang ₁ , Fang Yan ₁ , Yunfang Wang ₁

Affiliation

Impaired wound healing in diabetics usually leads to life-threatening complications. To develop a system for fastening skin wound healing efficiently and safely in diabetics, thermos-sensitive hydrogel containing the nanodrug, loaded in the form of gelatin microspheres (GMs), was designed to deliver curcumin (Cur) as a therapeutic drug. Cur is a naturally existing polyphenolic compound with a broad range of biological functions useful for potential therapies. Because Cur molecule has weakness in both bioavailability and in vivo stability, delivery of Cur requires assistance from other molecules to act as carrier vehicles in a sustained manner for therapeutic use. At first, self-assembly of Cur nanoparticles (CNPs) was done to improve bioavailability. The CNPs were further enclosed into GMs for responding to the matrix metalloproteinases (MMPs) that usually overexpress at diabetic nonhealing wound sites. The GMs containing CNPs were loaded into the thermos-sensitive hydrogel and were finally proved for the capacity of specially induced drug release at the wound bed, which promoted the efficacy in healing the standardized skin wounds in streptozotocin-induced diabetic mice. Our results indicated that the successfully developed CNP delivery system had the capacity to significantly promote skin wound healing, which suggested that it could have the potential to become a wound dressing with the properties of antioxidants and promotions of cell migration.

中文翻译：

姜黄素纳米粒子与MMP9响应和热敏感水凝胶的封装改善了糖尿病伤口的愈合。

糖尿病患者伤口愈合不良通常会导致危及生命的并发症。为了开发一种在糖尿病患者中有效，安全地固定皮肤伤口愈合的系统，设计了以明胶微球（GMs）形式载有纳米药物的热敏性水凝胶，用于递送姜黄素（Cur）作为治疗药物。Cur是一种天然存在的多酚化合物，具有广泛的生物学功能，可用于潜在的治疗。由于Cur分子在生物利用度和体内稳定性方面均较弱，因此Cur的递送需要其他分子的协助才能以持续方式充当载体，以用于治疗用途。首先，进行Cur纳米粒子（CNP）的自组装以提高生物利用度。将CNP进一步封闭在GM中，以对通常在糖尿病非愈合伤口部位过度表达的基质金属蛋白酶（MMP）作出反应。将含有CNP的GMs装入对热敏感的水凝胶中，并最终证明了在伤口床上有特殊诱导的药物释放能力，从而提高了在链脲佐菌素诱导的糖尿病小鼠中治愈标准化皮肤伤口的功效。我们的结果表明，成功开发的CNP输送系统具有显着促进皮肤伤口愈合的能力，这表明它可能具有成为具有抗氧化剂特性和促进细胞迁移的伤口敷料的潜力。将含有CNP的GMs装入对热敏感的水凝胶中，并最终证明了在伤口床上有特殊诱导的药物释放能力，从而提高了在链脲佐菌素诱导的糖尿病小鼠中治愈标准化皮肤伤口的功效。我们的结果表明，成功开发的CNP输送系统具有显着促进皮肤伤口愈合的能力，这表明它可能具有成为具有抗氧化剂特性和促进细胞迁移的伤口敷料的潜力。将含有CNP的GMs装入对热敏感的水凝胶中，并最终证明了在伤口床上有特殊诱导的药物释放能力，从而促进了在链脲佐菌素诱导的糖尿病小鼠中治愈标准化皮肤伤口的功效。我们的结果表明，成功开发的CNP输送系统具有显着促进皮肤伤口愈合的能力，这表明它可能具有成为具有抗氧化剂特性和促进细胞迁移的伤口敷料的潜力。

更新日期：2018-04-24

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