金纳米笼进入高对比度光声眼成像领域,Nanoscale

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金纳米笼进入高对比度光声眼成像领域
Nanoscale ( IF 5.8 ) Pub Date : 2018-04-23 00:00:00 , DOI: 10.1039/c8nr02866d
Sreejith Raveendran _{1,

2,

3,

4,

5} , Hoong-Ta Lim _{6,

7,

8,

9} , Toru Maekawa _{1,

2,

3,

4,

5} , Murukeshan Vadakke Matham _{6,

7,

8,

9} , D. Sakthi Kumar _{1,

2,

3,

4,

5}

Affiliation

具有多种形状和功能的生物惰性金纳米颗粒被广泛用作多种成像方式的造影剂（CA），即例如，电子显微镜，计算机断层扫描（CT），X射线和光声（PA）成像。然而，用于眼部诊断成像的新型紧凑型成像探头的测试始终具有挑战性。在这里，首次成功地证明了超快微波炉合成的金纳米笼（AuNcgs）用于高对比度PA眼成像。描述了用于快速合成的AuNcgs的合成，表征和在眼科诊断中的应用的方法。使用集成了可调纳秒脉冲激光的商用US成像扫描仪获取PA和超声（US）图像。这个集成的混合模态系统是用于成像的PA和US组合平台，可同时获取互补的结构信息和基于光吸收的信息。初始实验是使用装有不同浓度快速合成AuNcgs溶液的管子进行的。使用去核猪眼样本证明了生物PA和US成像。基于所获得的结果，设想AuNcgs可以用作高强度PA CA以在不久的将来潜在地诊断诸如葡萄膜黑素瘤的眼部疾病。

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Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging

Bioinert gold nanoparticles of various shapes and functionalities are widely accepted as contrast agents (CAs) for several modalities of imaging, viz., electron microscopy, computerized tomography (CT), X-ray and photoacoustic (PA) imaging. However, testing of novel compact-imaging probes for ocular diagnostic imaging is always challenging. Here, ultra-fast microwave oven synthesized gold nanocages (AuNcgs) were successfully demonstrated for high-contrast PA ocular imaging for the first time. Methods are described for the synthesis, characterization and application of quickly synthesized AuNcgs in diagnostic ocular imaging. PA and ultrasound (US) images were acquired using a commercial US imaging scanner integrated with a tunable nanosecond pulsed laser. This integrated hybrid-modality system is a combined PA and US platform for imaging which enabled acquiring of complementary structural and optical absorption-based information simultaneously. Initial experiments were conducted using tubings filled with solutions of different concentrations of quickly synthesized AuNcgs. Biological PA and US imagings were demonstrated using enucleated porcine eye samples. Based on the acquired results, it is envisaged that AuNcgs can be employed as a high strength PA CA to potentially diagnose ocular disease like uveal melanoma in the near future.

更新日期：2018-04-23

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