Charge-Determined LCST/UCST Behavior in Ionic Polypeptoids,Biomacromolecules

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Charge-Determined LCST/UCST Behavior in Ionic Polypeptoids
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-04-17 00:00:00 , DOI: 10.1021/acs.biomac.8b00240
Chao Xing ₁ , Zhekun Shi ₁ , Jiliang Tian ₁ , Jing Sun ₁ , Zhibo Li ₁

Affiliation

Stimuli-responsive polymers have received increasing interest for a variety of applications. Here, we report a series of unique charge-determined thermoresponsive polypeptoids synthesized by a combination of ring-opening polymerization and click chemistry. The LCST-type and UCST-type behavior is mainly dominated by the charge state on the side chain. Further, the phase transition temperature highly depends on the degree of polymerization, the side-chain architecture, the pH value, and so on. The obtained polypeptoid solutions exhibit good stability against temperature and salt concentration. To our knowledge, this report presents the first charge-determined LCST/UCST-type polymer from identical homopolymer backbone that displays a wide range of tunable cloudy points in aqueous media. We propose the hydrogen-bonding interaction plays a critical part on the solution behavior. These features make polypeptoids ideal candidates for highly designable stimuli-responsive polymeric materials.

中文翻译：

离子多肽中电荷确定的LCST / UCST行为

刺激响应性聚合物在各种应用中受到越来越多的关注。在这里，我们报告了一系列独特的电荷决定的热响应性多肽，它们是通过开环聚合和点击化学的结合而合成的。LCST型和UCST型行为主要由侧链上的电荷状态决定。此外，相变温度高度取决于聚合度，侧链结构，pH值等。所得的多肽溶液对温度和盐浓度表现出良好的稳定性。据我们所知，本报告介绍了第一种由相同均聚物主链进行电荷确定的LCST / UCST型聚合物，该聚合物在水性介质中显示出广泛的可调浊点。我们提出氢键相互作用在溶液行为中起关键作用。这些特征使类肽成为高度可设计的刺激响应性聚合物材料的理想候选者。

更新日期：2018-04-17

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