Engineering Persistent Luminescence Nanoparticles for Biological Applications: From Biosensing/Bioimaging to Theranostics,Accounts of Chemical Research

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Engineering Persistent Luminescence Nanoparticles for Biological Applications: From Biosensing/Bioimaging to Theranostics
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-04-17 00:00:00 , DOI: 10.1021/acs.accounts.7b00619
Shao-Kai Sun ₁ , He-Fang Wang ₂ , Xiu-Ping Yan _{3,

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Affiliation

Persistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting luminescence after ceasing excitation. Such a unique optical feature allows luminescence detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids and tissues. Besides, near-infrared (NIR) PLNPs have advantages of deep penetration and the reactivation of the persistent luminescence (PL) by red or NIR light. These features make the application of NIR-emitting PLNPs in long-term bioimaging no longer limited by the lifetime of PL. To take full advantage of PLNPs for biological applications, the versatile strategies for bridging PLNPs and biological system become increasingly significant for the design of PLNPs-based nanoprobes.

中文翻译：

工程上用于生物应用的持久性发光纳米颗粒：从生物传感/生物成像到治疗学

持久发光纳米粒子（PLNP）是独特的光学材料，在停止激发后会发出持久的发光。这种独特的光学功能无需连续的外部照明即可进行发光检测，从而避免了自发荧光的干扰以及生物液体和组织发出的光的散射。此外，近红外（NIR）PLNP具有穿透力强和通过红色或近红外光重新激活持久发光（PL）的优势。这些特征使得发射NIR的PLNP在长期生物成像中的应用不再受PL寿命的限制。为了充分利用PLNP的生物学应用，桥接PLNP和生物系统的通用策略对于基于PLNP的纳米探针的设计变得越来越重要。

更新日期：2018-04-17

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