Designs and Strategies for the Halo‐Functionalization of Diazo Compounds,Advanced Synthesis & Catalysis

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Designs and Strategies for the Halo‐Functionalization of Diazo Compounds
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-06-06 , DOI: 10.1002/adsc.201800340
Hari Datta Khanal ₁ , Raju S. Thombal ₁ , Shizuka Mei B. Maezono ₁ , Yong Rok Lee ₁

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Organo halides and their derivatives have received much attention in both the design and development of new synthetic reagents, drugs, and functional materials. In this review, we provide a comprehensive summary of recent advances and strategies in the halo‐functionalization of diazo compounds, including halogenation, dihalogenation, dihaloolefination, trifluoromethylation, trifluoromethylthiolation, and trifluoromethoxylation, using diverse halogenating agents. Special emphasis is placed on the challenges and achievements of these halogenation strategies. For selected examples, mechanisms leading to unusual reactivities and selectivities are discussed in detail to show the impressive and unique properties of these halogenation reactions. Furthermore, we hope to encourage the scientific community to explore the benefits of using diazo compounds as a straightforward and step‐economic alternative approach to the construction of carbon‐halogen bonds.

中文翻译：

重氮化合物卤代官能化的设计和策略

有机卤化物及其衍生物在新型合成试剂，药物和功能材料的设计和开发中都受到了广泛的关注。在这篇综述中，我们提供了使用多种卤化剂对重氮化合物进行卤代官能化的最新进展和策略的全面总结，包括卤化，二卤代化，二卤代烯烃化，三氟甲基化，三氟甲基硫代化和三氟甲氧基化。特别强调这些卤化策略的挑战和成就。对于选定的实例，将详细讨论导致异常反应性和选择性的机理，以显示这些卤化反应令人印象深刻且独特的性质。此外，

更新日期：2018-06-06

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