近红外光激活的热敏脂质体作为细菌生物膜的光热和抗生素协同治疗的有效药物。,ACS Applied Materials & Interfaces

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近红外光激活的热敏脂质体作为细菌生物膜的光热和抗生素协同治疗的有效药物。
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-13 00:00:00 , DOI: 10.1021/acsami.8b01327
Yu Zhao ₁ , Xiaomei Dai ₁ , Xiaosong Wei ₁ , Yunjian Yu ₁ , Xuelei Chen ₁ , Xinge Zhang ₁ , Chaoxing Li ₁

Affiliation

生物膜与慢性感染密切相关，难以根除。有效控制生物膜感染的有效治疗策略的开发仍然具有挑战性。针对生物膜结构，我们设计并制备了具有光热和抗生素协同治疗能力以消除铜绿假单胞菌的近红外激活的热敏脂质体。生物膜。带正电荷且体积小的脂质体有助于进入生物膜微通道并在感染部位局部释放抗生素。脂质体可以在37°C下保持稳定，并在45°C下释放约80％的抗生素。生物膜的分散率高达80％，与单独使用过量的抗生素相比，增长了7至8倍，这表明局部抗生素释放和光热联合疗法提高了抗菌效率。体内载药脂质体治疗铜绿假单胞菌引起的脓肿表现出突出的治疗作用。此外，光热处理可以刺激与bcl2相关的致癌基因3的表达，以防止正常组织受到热损伤。近红外激活的纳米颗粒载体具有巨大的治疗潜力，可通过热触发的药物释放和光热疗法显着增强抗生素的功效。

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Near-Infrared Light-Activated Thermosensitive Liposomes as Efficient Agents for Photothermal and Antibiotic Synergistic Therapy of Bacterial Biofilm

Biofilm is closely related to chronic infections and is difficult to eradicate. Development of effective therapy strategies to control biofilm infection is still challenging. Aiming at biofilm architecture, we designed and prepared near-infrared-activated thermosensitive liposomes with photothermal and antibiotic synergistic therapy capacity to eliminate Pseudomonas aeruginosa biofilm. The liposomes with positive charge and small size aided to enter the biofilm microchannels and locally released antibiotics in infection site. The liposomes could remain stable at 37 °C and release about 80% antibiotics over 45 °C. The biofilm dispersion rate was up to 80%, which was a 7- to 8-fold rise compared to excess antibiotic alone, indicating that the localized antibiotic release and photothermal co-therapy improved the antimicrobial efficiency. In vivo drug-loaded liposomes in treating P. aeruginosa-induced abscess exhibited an outstanding therapeutic effect. Furthermore, photothermal treatment could stimulate the expression of bcl2-associated athanogene 3 to prevent normal tissue from thermal damage. The near-infrared-activated nanoparticle carriers had the tremendous therapeutic potential to dramatically enhance the efficacy of antibiotics through thermos-triggered drug release and photothermal therapy.

更新日期：2018-04-13

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