Palladium-Catalyzed C-2 C–H Heteroarylation of Chiral Oxazolines: Diverse Synthesis of Chiral Oxazoline Ligands,Organic Letters

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Palladium-Catalyzed C-2 C–H Heteroarylation of Chiral Oxazolines: Diverse Synthesis of Chiral Oxazoline Ligands
Organic Letters ( IF 4.9 ) Pub Date : 2015-11-25 00:00:00 , DOI: 10.1021/acs.orglett.5b03041
Tuo Xi ₁ , Yuncai Mei ₁ , Zhan Lu ₁

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A direct, efficient, and practical protocol to install a chiral oxazoline unit onto aryl/heteroaryl rings via palladium-catalyzed C–H functionalization of 2-positions of oxazolines with a variety of halides using dppe as the ligand has been developed. Various chiral oxazoline ligands could be synthesized, even in a 10-g scale process. This protocol is a good supplement to traditional methods and for diverse synthesis of chiral oxazoline ligands.

中文翻译：

钯催化的手性恶唑啉的C-2 C–H杂芳基化：手性恶唑啉配体的不同合成

一种直接，有效，实用的方案，已开发出一种手性恶唑啉单元，通过钯催化以dppe为配体的各种卤化物通过钯催化的恶唑啉2-位的CH-H官能化，将手性恶唑啉单元安装在芳基/杂芳基环上。即使以10 g规模的过程，也可以合成各种手性恶唑啉配体。该协议是对传统方法和手性恶唑啉配体的各种合成的良好补充。

更新日期：2015-11-25

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