Remotely Controlled Red Blood Cell Carriers for Cancer Targeting and Near‐Infrared Light‐Triggered Drug Release in Combined Photothermal–Chemotherapy,Advanced Functional Materials

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Remotely Controlled Red Blood Cell Carriers for Cancer Targeting and Near‐Infrared Light‐Triggered Drug Release in Combined Photothermal–Chemotherapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2015-02-25 , DOI: 10.1002/adfm.201500061
Xiaoqi Sun ₁ , Chao Wang ₁ , Min Gao ₁ , Aiyan Hu ₁ , Zhuang Liu ₁

Affiliation

Red blood cells (RBCs), the “innate carriers” in blood vessels, are gifted with many unique advantages in drug transportation over synthetic drug delivery systems (DDSs). Herein, a tumor angiogenesis targeting, light stimulus‐responsive, RBC‐based DDS is developed by incorporating various functional components within the RBC platform. An albumin bound near‐infrared (NIR) dye, together with a chemotherapy drug doxorubicin, is encapsulated inside RBCs, the surfaces of which are modified with a targeting peptide to allow cancer targeting. Under stimulation by an external NIR laser, the membrane of the RBCs would be destroyed by the light‐induced photothermal heating, resulting in effective drug release. As a proof of principle, RBC‐based cancer cell targeted drug delivery and light‐controlled drug release is demonstrated in vitro, achieving a marked synergistic therapeutic effect through the combined photothermal–chemotherapy. This work presents a novel design of smart RBC carriers, which are inherently biocompatible, promising for targeted combination therapy of cancer.

中文翻译：

远程控制的红细胞载体可用于靶向癌症和光热化学疗法中近红外光触发的药物释放

红细胞（RBC）是血管中的“先天携带者”，与合成药物递送系统（DDS）相比，在药物运输方面具有许多独特的优势。本文中，通过在RBC平台中整合各种功能组件，开发了靶向肿瘤血管生成，基于光刺激响应，基于RBC的DDS。白蛋白结合的近红外（NIR）染料与化疗药物阿霉素一起被封装在RBC内，RBC的表面被靶向肽修饰以实现癌症靶向。在外部NIR激光的刺激下，光诱导的光热加热会破坏RBC的膜，从而导致有效的药物释放。作为原理证明，已在体外证明了基于RBC的癌细胞靶向药物递送和光控药物释放，通过光热化学疗法的组合达到显着的协同治疗作用。这项工作提出了一种新颖的智能RBC载体设计，该载体具有固有的生物相容性，有望用于癌症的靶向联合治疗。

更新日期：2015-02-25

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