Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles,Accounts of Chemical Research

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Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-04-11 00:00:00 , DOI: 10.1021/acs.accounts.8b00062
Haoxing Wu ₁ , Neal K Devaraj ₂

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Bioorthogonal chemistry has found increased application in living systems over the past decade. In particular, tetrazine bioorthogonal chemistry has become a powerful tool for imaging, detection, and diagnostic purposes, as reflected in the increased number of examples reported in the literature. The popularity of tetrazine ligations are likely due to rapid and tunable kinetics, the existence of high quality fluorogenic probes, and the selectivity of reaction. In this Account, we summarize our recent efforts to advance tetrazine bioorthogonal chemistry through improvements in synthetic methodology, with an emphasis on developing new routes to tetrazines and expanding the range of useful dienophiles. These efforts have removed specific barriers that previously limited tetrazine ligations and have broadened their potential applications.

中文翻译：

新型 Tetrazine 和 Dienophiles 合成驱动的 Tetrazine 生物正交化学进展

在过去的十年中，生物正交化学在生命系统中的应用越来越多。特别是，四嗪生物正交化学已成为成像、检测和诊断目的的强大工具，这反映在文献中报道的实例数量的增加中。tetrazine 连接的流行可能是由于快速且可调的动力学、高质量荧光探针的存在以及反应的选择性。在本报告中，我们总结了我们最近通过改进合成方法推进四嗪生物正交化学的努力，重点是开发四嗪的新途径和扩大有用的亲二试剂的范围。这些努力消除了以前限制 tetrazine 连接的特定障碍，并拓宽了它们的潜在应用。

更新日期：2018-04-11

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