Municipal Wastewater as a Microbial Surveillance Platform for Enteric Diseases: A Case Study for Salmonella and Salmonellosis,Environmental Science & Technology

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Municipal Wastewater as a Microbial Surveillance Platform for Enteric Diseases: A Case Study for Salmonella and Salmonellosis
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2018-04-09 , DOI: 10.1021/acs.est.8b00163
T. Yan ₁ , P. O’Brien ₂ , J. M. Shelton ₁ , A. C. Whelen _{2,

3} , E. Pagaling ₁

Affiliation

Municipal wastewater (MW) contains a conglomeration of human enteric microbiota from a community and, hence, represents a potential surveillance tool for gastrointestinal infectious disease burden at the community level. To evaluate this, the concentration of Salmonella in MW samples from Honolulu, Hawaii, was monitored over a 54-week period, which showed positive and significant linear and rank correlation with clinical salmonellosis case numbers over the same period. Salmonella isolates were obtained from the MW samples and then compared with clinical isolates obtained by the Hawaii Department of Health State Laboratories over the same period. The MW isolate collection contained 34 serotypes, and the clinical isolate collection contained 47 serotypes, 21 of which were shared between the two isolate collections, including nine of the 12 most commonly detected clinical serotypes. Most notably, nine Salmonella strains, including one outbreak-associated Paratyphi B strain and eight other clinically rare strains, were shared and concurrently detected between the MW and the clinical isolate collections, indicating the feasibility of using enteric pathogens in the MW as a timely indication of community enteric disease activity.

中文翻译：

市政废水作为肠道疾病的微生物监测平台：沙门氏菌和沙门氏菌病的案例研究

市政废水（MW）包含来自社区的人类肠道菌群，因此代表了社区一级胃肠道传染病负担的潜在监视工具。为了对此进行评估，在54周的时间内对来自夏威夷檀香山的MW样品中沙门氏菌的浓度进行了监测，结果显示与同期沙门氏菌病病例数呈正相关且显着的线性和等级相关性。沙门氏菌从MW样品中获得了分离株，然后与同期夏威夷健康局国家实验室获得的临床分离株进行了比较。MW分离株集合包含34种血清型，临床分离株集合包含47种血清型，其中21种在两个分离株集合之间共享，包括12种最常检测到的临床血清型。最值得注意的是，MW和临床分离株之间共享并同时检测了9株沙门氏菌菌株，其中包括1株与暴发相关的副伤寒B菌株和8株其他临床上罕见的菌株，这表明在MW中使用肠道病原体作为及时适应症的可行性肠道疾病的活动。

更新日期：2018-04-10

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