Palladium-catalyzed aerobic regio- and stereo-selective olefination reactions of phenols and acrylates via direct dehydrogenative C(sp2)–O cross-coupling†,Chemical Communications

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Palladium-catalyzed aerobic regio- and stereo-selective olefination reactions of phenols and acrylates via direct dehydrogenative C(sp2)–O cross-coupling†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-04-05 00:00:00 , DOI: 10.1039/c8cc01226a
Yun-Bin Wu _{1,

2,

3,

4,

5} , Dan Xie _{1,

2,

3,

4,

5} , Zhong-Lin Zang _{1,

2,

3,

4,

5} , Cheng-He Zhou _{1,

2,

3,

4,

5} , Gui-Xin Cai _{1,

2,

3,

4,

5}

Affiliation

An efficient olefination protocol for the oxidative dehydrogenation of phenols and acrylates has been achieved using a palladium catalyst and O₂ as the sole oxidant. This reaction exhibits high regio- and stereo-selectivity (E-isomers) with moderate to excellent isolated yields and a wide substrate scope (32 examples) including ethyl vinyl ketone and endofolliculina.

中文翻译：

通过直接脱氢的C（sp ²）-O交叉偶联，钯催化的苯酚和丙烯酸酯的好氧区域和立体选择性烯化反应†

使用钯催化剂和O ₂作为唯一氧化剂，已经实现了用于酚类和丙烯酸酯类氧化脱氢的有效烯烃化方案。该反应表现出高的区域选择性和立体选择性（E-异构体），具有中等至优异的分离产率，并且底物范围宽（32个实施例），包括乙基乙烯基酮和毛囊内膜菌素。

更新日期：2018-04-05

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