A new fluorosulfonylation reagent 1-bromoethene-1-sulfonyl fluoride was developed (1-Br-ESF). This unique reagent possesses three addressable handles (vinyl, bromide, and sulfonyl fluoride) and has great potential to function as a tris-electrophile and as a sulfur(VI) fluoride exchange (SuFEx) clickable material to enrich the SuFEx tool cabinet. The application of this reagent for regioselective synthesis of 5-sulfonylfluoro isoxazoles has been realized through a [3+2] cycloaddition with N-hydroxybenzimidoyl chlorides. This practical protocol provides a general and direct route to functionalized isoxazoles possessing sulfonyl fluoride moieties.

中文翻译：

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一种新型SuFEx可点击试剂1-溴乙烯-1-磺酰氟（1-Br-ESF）及其在5-磺酰氟异恶唑的区域选择性构建中的应用†

开发了一种新的氟磺酰化试剂1-溴乙烯-1-磺酰氟（1-Br-ESF）。这种独特的试剂具有三个可寻址的手柄（乙烯基，溴化物和磺酰氟），并且具有巨大的潜力，可以用作三亲电子试剂和硫（VI）氟化物交换（SuFEx）可点击材料，以丰富SuFEx工具柜。通过与N-羟基苯甲酰亚胺基氯进行[3 + 2]环加成反应，已经实现了该试剂在5-磺酰基氟异恶唑的区域选择性合成中的应用。该实用方案提供了具有磺酰氟部分的官能化异恶唑的一般直接途径。