The outcome of scaffold-based stem cell transplantation remains unsatisfied due to the poor survival of transplanted cells. One of the major hurdles associated with the stem cell survival is the immune rejection, which can be effectively reduced by the use of immunosuppressant. However, ideal localized and sustained release of immunosuppressant is difficult to be realized, because it is arduous to hold the drug delivery system within scaffold for a long period of time. In the present study, the sustained release of immunosuppressant for the purpose of improving the survival of stem cells was successfully realized by a nanoparticle-anchoring hydrogel scaffold we developed.

中文翻译：

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纳米粒子锚定水凝胶支架缓释免疫抑制剂提高了移植的干细胞的存活率和组织再生。

基于支架的干细胞移植的结果仍然不令人满意，因为移植细胞的存活率很低。与干细胞存活相关的主要障碍之一是免疫排斥，可以通过使用免疫抑制剂有效地减少免疫排斥。然而，难以实现理想的免疫抑制剂的局部和持续释放，因为将药物递送系统长时间保持在支架内是很困难的。在本研究中，我们开发的纳米颗粒锚定水凝胶支架成功实现了为提高干细胞存活率而持续释放的免疫抑制剂。