Reaction Mechanism of Prephenate Dehydrogenase from the Alternative Tyrosine Biosynthesis Pathway in Plants,ChemBioChem

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Reaction Mechanism of Prephenate Dehydrogenase from the Alternative Tyrosine Biosynthesis Pathway in Plants
ChemBioChem ( IF 2.6 ) Pub Date : 2018-05-02 , DOI: 10.1002/cbic.201800085
Cynthia K Holland ₁ , Joseph M Jez ₁

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Small changes, big impact: Active site mutants of prephenate dehydrogenase from Glycine max (soybean) were biochemically analyzed by using molecular docking and steady‐state kinetics. The results suggested that even small changes in the active site led to drastic reductions in catalytic efficiency, thus leading us to conclude that nature has optimized this plant tyrosine biosynthetic enzyme.