The synthesis and photochemical properties of two novel selenium zinc(II) phthalocyanines, a lipid-soluble 2,9(10),16(17),23(24)-tetrakis [(2-dimethylamino)ethylselanyl]phthalocyaninato zinc(II) (4) and its water-soluble quaternized derivative 2,9(10),16(17),23(24)-tetrakis [(2- trimethylammonium)ethylselanyl]phthalocyaninato zinc(II) tetraiodide (5), were investigated. Maximum absorption values were 689 nm and 684 nm for 4 and 5 in DMF, respectively. In addition, phthalocyanines were revealed to be very efficient singlet oxygen generators with high values of Φ_Δ 0.74 and 0.84 for 4 and 5 in DMF, and they were photostable over the irradiation times studied. The photodynamic effect were evaluated on CT26 colon carcinoma cells. After light exposure, 4 and 5 were found to be cytotoxic, and IC₅₀ values were 0.5 ± 0.1 μM and 2.3 ± 0.6 μM, respectively. The production of a greater amount of reactive oxygen species after phthalocyanines irradiation would be responsible for its potent phototoxic action on CT26 colon carcinoma cells.

两种新型硒化锌硒酞菁类化合物的合成及光化学性质，脂溶性2,9（10），16（17），23（24）-四[[2-（2-二甲基氨基）乙基硒基]酞菁锌（II） （4）及其水溶性季铵化衍生物2,9（10），16（17），23（24）-四[[（2-三甲基铵）乙基硒基]酞菁锌四碘化锌（II）（5）。DMF中4和5的最大吸收值分别为689 nm和684 nm。此外，酞菁被发现是非常有效的单重态氧发生器与Φ的高值_Δ为0.74和0.84 4和5在DMF中，它们在研究的辐射时间内是光稳定的。评价对CT26结肠癌细胞的光动力作用。曝光后，发现4和5具有细胞毒性，IC ₅₀值分别为0.5±0.1μM和2.3±0.6μM。酞菁辐照后产生大量的活性氧将导致其对CT26结肠癌细胞的强光毒性作用。