Chiral Sensing Platform Based on the Self-Assemblies of Diphenylalanine and Oxalic Acid,Analytical Chemistry

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Chiral Sensing Platform Based on the Self-Assemblies of Diphenylalanine and Oxalic Acid
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-03-29 00:00:00 , DOI: 10.1021/acs.analchem.8b00762
Lili Guo ₁ , Baozhu Yang ₁ , Datong Wu ₁ , Yongxin Tao ₁ , Yong Kong ₁

Affiliation

Molecular self-assemblies offer a promising strategy for the synthesis of advanced materials for the construction of novel chiral sensing systems, and latest innovations on such self-assemblies are focused on simple building blocks in biology such as nucleic acids, lipids, and peptides. Herein, the self-assemblies of diphenylalanine (FF) and oxalic acid (OA) were prepared as the chiral sensing device for the recognition of tryptophan (Trp) isomers. Interestingly, the self-assemblies composed of OA and FF with different charging states (neutral, positively charged, and negatively charged) exhibited quite different morphologies, resulting in significantly different chiral recognition ability toward the Trp isomers. Also, in this work, the temperature sensitivity and chiral selectivity of the proposed FF-OA self-assemblies were also studied. From a practical point of view, the FF-OA self-assemblies were finally applied for the determination of precise levels of d-Trp in the racemic mixture of Trp isomers.

中文翻译：

基于二苯丙氨酸和草酸自组装的手性传感平台

分子自组装为合成新型手性传感系统的先进材料提供了一种有前途的策略，而此类自组装的最新创新集中于生物学上的简单构件，如核酸，脂质和肽。在此，制备了二苯丙氨酸（FF）和草酸（OA）的自组装体作为用于识别色氨酸（Trp）异构体的手性传感装置。有趣的是，由具有不同带电状态（中性，带正电和带负电）的OA和FF组成的自组装体表现出非常不同的形态，从而导致对Trp异构体的手性识别能力明显不同。另外，在这项工作中，还研究了所提出的FF-OA自组装的温度敏感性和手性选择性。Trp异构体的外消旋混合物中的d -Trp。

更新日期：2018-03-29

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