Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides†,Chemical Communications

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Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-28 00:00:00 , DOI: 10.1039/c8cc01577e
Xiao-Yu Lu _{1,

2,

3,

4,

5} , Mei-Lan Hong _{1,

2,

3,

4} , Hai-Pin Zhou _{1,

2,

3,

4} , Yue Wang _{1,

2,

3,

4} , Jin-Yu Wang _{1,

2,

3,

4} , Xiu-Tao Ge _{1,

2,

3,

4}

Affiliation

The stereoselective synthesis of tri-substituted alkenes is challenging. Herein, we report a Ni-catalyzed regio- and stereo-selective hydroalkylation of internal alkynes with non-activated alkyl halides. This method does not use any sensitive organometallic reagents and shows good functional group compatibility, which enables the efficient synthesis of many tri-substituted olefins from readily available coupling partners. It also provides a straightforward method for the modification of bioactive organic molecules.

中文翻译：

通过内部炔烃与未活化的烷基卤的镍催化加氢烷基化反应合成三取代的烯烃†

三取代烯烃的立体选择性合成具有挑战性。在此，我们报道了内部炔烃与未活化的烷基卤化物的镍催化的区域和立体选择性加氢烷基化。该方法不使用任何敏感的有机金属试剂，并且显示出良好的官能团相容性，这使得能够从容易获得的偶联配偶体高效合成许多三取代的烯烃。它还提供了一种直接的方法来修饰生物活性有机分子。

更新日期：2018-03-28

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