A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents†,Chemical Communications

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A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-26 00:00:00 , DOI: 10.1039/c7cc09142g
Mirao Zha _{1,

2,

3,

4,

5} , Ping Lin _{1,

2,

3,

4,

5} , Hongwei Yao _{1,

2,

3,

4,

5} , Yibing Zhao _{1,

2,

3,

4,

5} , Chuanliu Wu _{1,

2,

3,

4,

5}

Affiliation

Bicyclic peptides have been attractive scaffolds for developing high affinity reagents for biomacromolecules. Here we report a general phage-screening strategy for the development of bicyclic peptide ligands constrained with isomerically-forbidden disulfide bridges without elaborate chemical modifications and recourses to genetic code reprogramming.

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