Synthesis ( IF 2.2 ) Pub Date : 2018-03-20 , DOI: 10.1055/s-0037-1609364 Ashwini Shirsale 1 , Yogesh Patil 1 , Girish Rawal 1 , Jagadish Pabba 1 , Guillaume Berthon 2 , Ravindra Sonawane 1 , Vikas Sikervar 1
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Abstract
The synthesis of previously unreported pyrazolo-pyrimidinones and isoxazolo-pyrimidinones are achieved via metal-free coupling of oxazine-2,6-diones with pyrazolidinone and isoxazolidinone, respectively. The synthesis provides easy access to a variety of novel 2-dimensional building blocks that can be derivatized to generate a range of drug- and agro-like molecules.
The synthesis of previously unreported pyrazolo-pyrimidinones and isoxazolo-pyrimidinones are achieved via metal-free coupling of oxazine-2,6-diones with pyrazolidinone and isoxazolidinone, respectively. The synthesis provides easy access to a variety of novel 2-dimensional building blocks that can be derivatized to generate a range of drug- and agro-like molecules.
中文翻译：
一种方便，简便的无金属方法从恶嗪-2,6-二酮官能化的双环嘧啶酮。
摘要
先前未报道的吡唑并嘧啶酮和异恶唑并嘧啶酮的合成分别通过恶嗪-2，6-二酮与吡唑烷酮和异恶唑烷酮的无金属偶联而实现。通过合成，可以轻松获取各种新颖的二维构建基块，这些基块可以进行衍生化以生成一系列药物和农业类分子。
先前未报道的吡唑并嘧啶酮和异恶唑并嘧啶酮的合成分别通过恶嗪-2，6-二酮与吡唑烷酮和异恶唑烷酮的无金属偶联而实现。通过合成，可以轻松获取各种新颖的二维构建基块，这些基块可以进行衍生化以生成一系列药物和农业类分子。
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