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Ultraporous, Compressible, Wettable Polylactide/Polycaprolactone Sponges for Tissue Engineering
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-03-20 00:00:00 , DOI: 10.1021/acs.biomac.8b00434 Michael Mader 1 , Valérie Jérôme 2 , Ruth Freitag 2 , Seema Agarwal 1 , Andreas Greiner 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-03-20 00:00:00 , DOI: 10.1021/acs.biomac.8b00434 Michael Mader 1 , Valérie Jérôme 2 , Ruth Freitag 2 , Seema Agarwal 1 , Andreas Greiner 1
Affiliation
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Ultraporous, degradable sponges made of either polylactide or of blends of polylactide/poly(ε-caprolactone) are prepared by freeze-drying of dispersions of short electrospun fibers and subsequent thermal annealing. The sponges feature ultrahigh porosity (99.6%), a hierarchical cellular structure, and high reversible compressibility with fast recovery from deformation in the dry as well as in the wet state. The sponge properties depend on the fiber dispersion concentration and the annealing temperature. Sponge characteristics like fiber density (2.5–20 mg/cm3), size, shape, crystallinity, mechanical strength, wetability, and structural integrity are user adjustable. Cell culture experiments were successfully performed with Jurkat cells with Confocal Laser Scanning Microscopy and MTT staining showing rapid cell proliferation. Live/Dead staining demonstrated high viability of the seeded cells. The sponge characteristics and modifications investigated and presented here reveal that these sponges are highly promising for tissue engineering applications.
中文翻译：
用于组织工程的超多孔，可压缩，可润湿的聚丙交酯/聚己内酯海绵
由聚丙交酯或聚丙交酯/聚（ε-己内酯）的混合物制成的超多孔可降解海绵，是通过将短的电纺纤维的分散液冷冻干燥并随后进行热退火而制备的。海绵具有超高孔隙率（99.6％），分层的孔结构和高可逆压缩性，可从干燥和潮湿状态下快速恢复变形。海绵的性能取决于纤维分散体的浓度和退火温度。海绵特性，例如纤维密度（2.5–20 mg / cm 3），尺寸，形状，结晶度，机械强度，可湿性和结构完整性可由用户调整。用共聚焦激光扫描显微镜和Jurkat细胞成功进行细胞培养实验，MTT染色显示细胞快速增殖。活/死染色证明了接种细胞的高生存力。此处研究和介绍的海绵特性和改性表明，这些海绵在组织工程应用中非常有前途。
更新日期：2018-03-20
中文翻译：
用于组织工程的超多孔，可压缩，可润湿的聚丙交酯/聚己内酯海绵
由聚丙交酯或聚丙交酯/聚（ε-己内酯）的混合物制成的超多孔可降解海绵，是通过将短的电纺纤维的分散液冷冻干燥并随后进行热退火而制备的。海绵具有超高孔隙率（99.6％），分层的孔结构和高可逆压缩性，可从干燥和潮湿状态下快速恢复变形。海绵的性能取决于纤维分散体的浓度和退火温度。海绵特性，例如纤维密度（2.5–20 mg / cm 3），尺寸，形状，结晶度，机械强度，可湿性和结构完整性可由用户调整。用共聚焦激光扫描显微镜和Jurkat细胞成功进行细胞培养实验，MTT染色显示细胞快速增殖。活/死染色证明了接种细胞的高生存力。此处研究和介绍的海绵特性和改性表明，这些海绵在组织工程应用中非常有前途。
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