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Raspberry anthocyanin consumption prevents diet-induced obesity by alleviating oxidative stress and modulating hepatic lipid metabolism†
Food & Function ( IF 5.1 ) Pub Date : 2018-03-20 00:00:00 , DOI: 10.1039/c7fo02061a Tao Wu 1, 2, 3, 4, 5 , Lu Yang 1, 2, 3 , Xueqi Guo 1, 2, 3 , Min Zhang 1, 2, 3, 4, 5 , Rui Liu 1, 2, 3, 4, 5 , Wenjie Sui 1, 2, 3, 6, 7
Food & Function ( IF 5.1 ) Pub Date : 2018-03-20 00:00:00 , DOI: 10.1039/c7fo02061a Tao Wu 1, 2, 3, 4, 5 , Lu Yang 1, 2, 3 , Xueqi Guo 1, 2, 3 , Min Zhang 1, 2, 3, 4, 5 , Rui Liu 1, 2, 3, 4, 5 , Wenjie Sui 1, 2, 3, 6, 7
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Evidence indicates that raspberries have beneficial effects on chronic diseases. The objective of this study was to examine the beneficial effects of raspberry anthocyanin (RA) on high fat diet-induced obesity and investigate the underlying molecular mechanism. C57BL/6 mice were administered a low-fat diet, high-fat diet, and high-fat diet supplemented with RA at a dose of 200 mg kg−1 of food for 12 weeks. It was found that RA reduced the body weight gain by 63.7%. Furthermore, RA significantly elevated serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities and fecal butyric acid level, remarkably reduced the serum and hepatic lipid profiles, and markedly down-regulated the expression of the tumor necrosis factor α (TNFα), interleukin-6 (IL-6), and nuclear factor κB (NF-κB) genes. Metabolomics analysis conducted using gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) indicated that RA administration promoted the recovery of metabolites involved in glycerophospholipid metabolism, insulin signaling pathway, and glutathione metabolism in the livers of obese mice. These findings suggest that RA may ameliorate diet-induced obesity by alleviating oxidative stress and modulating lipid metabolism.
中文翻译：
食用树莓花青素可通过减轻氧化应激和调节肝脂质代谢来预防饮食引起的肥胖症†
有证据表明，覆盆子对慢性病具有有益的作用。这项研究的目的是检查覆盆子花色苷（RA）对高脂饮食诱导的肥胖的有益作用，并研究其潜在的分子机制。对C57BL / 6小鼠进行低脂饮食，高脂饮食和补充RA的高脂饮食，剂量为200 mg kg -1食物持续12周。发现RA使体重增加减少了63.7％。此外，RA显着提高了血清超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）活性和粪便丁酸水平，显着降低了血清和肝脂质谱，并显着下调了肿瘤坏死因子α（TNFα）的表达。 ），白介素6（IL-6）和核因子κB（NF-κB）基因。使用气相色谱飞行时间质谱（GC-TOF / MS）进行的代谢组学分析表明，RA给药促进了肥胖小鼠肝脏中与甘油磷脂代谢，胰岛素信号通路和谷胱甘肽代谢有关的代谢物的恢复。这些发现表明RA可以通过减轻氧化应激和调节脂质代谢来改善饮食引起的肥胖。
更新日期：2018-03-20
中文翻译：
食用树莓花青素可通过减轻氧化应激和调节肝脂质代谢来预防饮食引起的肥胖症†
有证据表明，覆盆子对慢性病具有有益的作用。这项研究的目的是检查覆盆子花色苷（RA）对高脂饮食诱导的肥胖的有益作用，并研究其潜在的分子机制。对C57BL / 6小鼠进行低脂饮食，高脂饮食和补充RA的高脂饮食，剂量为200 mg kg -1食物持续12周。发现RA使体重增加减少了63.7％。此外，RA显着提高了血清超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）活性和粪便丁酸水平，显着降低了血清和肝脂质谱，并显着下调了肿瘤坏死因子α（TNFα）的表达。 ），白介素6（IL-6）和核因子κB（NF-κB）基因。使用气相色谱飞行时间质谱（GC-TOF / MS）进行的代谢组学分析表明，RA给药促进了肥胖小鼠肝脏中与甘油磷脂代谢，胰岛素信号通路和谷胱甘肽代谢有关的代谢物的恢复。这些发现表明RA可以通过减轻氧化应激和调节脂质代谢来改善饮食引起的肥胖。
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